Life-on-a-chip

Mary E. Lidstrom, Deirdre R. Meldrum

Research output: Contribution to journalArticle

141 Scopus citations

Abstract

Mechanistic studies of cellular processes are usually carried out with large populations of cells. However, parameters that are measured as averages of large populations can be misleading. For instance, an apparently linear response to a signal could, in fact, reflect an increasing number of cells in the population that have switched from 'off' to 'on', rather than a graded increase in response by all the cells. At present, the study of single cells is challenging, but new technologies mean it might soon be a reality.

Original languageEnglish (US)
Pages (from-to)158-164
Number of pages7
JournalNature Reviews Microbiology
Volume1
Issue number2
DOIs
StatePublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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