Life history trade-offs in cancer evolution

C Athena Aktipis, Amy M. Boddy, Robert A. Gatenby, Joel S. Brown, Carlo Maley

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Somatic evolution during cancer progression and therapy results in tumour cells that show a wide range of phenotypes, which include rapid proliferation and quiescence. Evolutionary life history theory may help us to understand the diversity of these phenotypes. Fast life history organisms reproduce rapidly, whereas those with slow life histories show less fecundity and invest more resources in survival. Life history theory also provides an evolutionary framework for phenotypic plasticity, which has potential implications for understanding 'cancer stem cells'. Life history theory suggests that different therapy dosing schedules might select for fast or slow life history cell phenotypes, with important clinical consequences.

Original languageEnglish (US)
Pages (from-to)883-892
Number of pages10
JournalNature Reviews Cancer
Volume13
Issue number12
DOIs
StatePublished - 2013

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Phenotype
Clonal Evolution
Neoplasms
Neoplastic Stem Cells
Fertility
Appointments and Schedules
Therapeutics
Life History Traits

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Life history trade-offs in cancer evolution. / Aktipis, C Athena; Boddy, Amy M.; Gatenby, Robert A.; Brown, Joel S.; Maley, Carlo.

In: Nature Reviews Cancer, Vol. 13, No. 12, 2013, p. 883-892.

Research output: Contribution to journalArticle

Aktipis, CA, Boddy, AM, Gatenby, RA, Brown, JS & Maley, C 2013, 'Life history trade-offs in cancer evolution', Nature Reviews Cancer, vol. 13, no. 12, pp. 883-892. https://doi.org/10.1038/nrc3606
Aktipis, C Athena ; Boddy, Amy M. ; Gatenby, Robert A. ; Brown, Joel S. ; Maley, Carlo. / Life history trade-offs in cancer evolution. In: Nature Reviews Cancer. 2013 ; Vol. 13, No. 12. pp. 883-892.
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