Life history trade-offs in cancer evolution

C Athena Aktipis; Amy M. Boddy; Robert A. Gatenby; Joel S. Brown; Carlo Maley

doi:10.1038/nrc3606

Life history trade-offs in cancer evolution

C Athena Aktipis, Amy M. Boddy, Robert A. Gatenby, Joel S. Brown, Carlo Maley

Psychology

Research output: Contribution to journal › Review article › peer-review

140 Scopus citations

Abstract

Somatic evolution during cancer progression and therapy results in tumour cells that show a wide range of phenotypes, which include rapid proliferation and quiescence. Evolutionary life history theory may help us to understand the diversity of these phenotypes. Fast life history organisms reproduce rapidly, whereas those with slow life histories show less fecundity and invest more resources in survival. Life history theory also provides an evolutionary framework for phenotypic plasticity, which has potential implications for understanding 'cancer stem cells'. Life history theory suggests that different therapy dosing schedules might select for fast or slow life history cell phenotypes, with important clinical consequences.

Original language	English (US)
Pages (from-to)	883-892
Number of pages	10
Journal	Nature Reviews Cancer
Volume	13
Issue number	12
DOIs	https://doi.org/10.1038/nrc3606
State	Published - 2013

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/nrc3606

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title = "Life history trade-offs in cancer evolution",

abstract = "Somatic evolution during cancer progression and therapy results in tumour cells that show a wide range of phenotypes, which include rapid proliferation and quiescence. Evolutionary life history theory may help us to understand the diversity of these phenotypes. Fast life history organisms reproduce rapidly, whereas those with slow life histories show less fecundity and invest more resources in survival. Life history theory also provides an evolutionary framework for phenotypic plasticity, which has potential implications for understanding 'cancer stem cells'. Life history theory suggests that different therapy dosing schedules might select for fast or slow life history cell phenotypes, with important clinical consequences.",

author = "Aktipis, {C Athena} and Boddy, {Amy M.} and Gatenby, {Robert A.} and Brown, {Joel S.} and Carlo Maley",

note = "Funding Information: The authors thank A. Nedelcu, A. Caulin and A. J. Figuredo for thoughtful and thought-provoking discussions during the development of these ideas. This work was supported in part by Research Scholar Grant number 117209-RSG-09-163-01-CNE from the American Cancer Society, by US National Institutes of Health (NIH) grants F32 CA144331, R01 CA149566, R01 CA170595, R01 CA140657 and U54 CA143970, and by a grant from the McDonnell Foundation 220020270.",

year = "2013",

doi = "10.1038/nrc3606",

language = "English (US)",

volume = "13",

pages = "883--892",

journal = "Nature Reviews Cancer",

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AU - Aktipis, C Athena

AU - Boddy, Amy M.

AU - Gatenby, Robert A.

AU - Brown, Joel S.

AU - Maley, Carlo

N1 - Funding Information: The authors thank A. Nedelcu, A. Caulin and A. J. Figuredo for thoughtful and thought-provoking discussions during the development of these ideas. This work was supported in part by Research Scholar Grant number 117209-RSG-09-163-01-CNE from the American Cancer Society, by US National Institutes of Health (NIH) grants F32 CA144331, R01 CA149566, R01 CA170595, R01 CA140657 and U54 CA143970, and by a grant from the McDonnell Foundation 220020270.

PY - 2013

Y1 - 2013

N2 - Somatic evolution during cancer progression and therapy results in tumour cells that show a wide range of phenotypes, which include rapid proliferation and quiescence. Evolutionary life history theory may help us to understand the diversity of these phenotypes. Fast life history organisms reproduce rapidly, whereas those with slow life histories show less fecundity and invest more resources in survival. Life history theory also provides an evolutionary framework for phenotypic plasticity, which has potential implications for understanding 'cancer stem cells'. Life history theory suggests that different therapy dosing schedules might select for fast or slow life history cell phenotypes, with important clinical consequences.

AB - Somatic evolution during cancer progression and therapy results in tumour cells that show a wide range of phenotypes, which include rapid proliferation and quiescence. Evolutionary life history theory may help us to understand the diversity of these phenotypes. Fast life history organisms reproduce rapidly, whereas those with slow life histories show less fecundity and invest more resources in survival. Life history theory also provides an evolutionary framework for phenotypic plasticity, which has potential implications for understanding 'cancer stem cells'. Life history theory suggests that different therapy dosing schedules might select for fast or slow life history cell phenotypes, with important clinical consequences.

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Life history trade-offs in cancer evolution

Abstract

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