Life history theory and breast cancer risk

Methodological and theoretical challenges: Response to "Is estrogen receptor negative breast cancer risk associated with a fast life history strategy"?

Research output: Contribution to journalComment/debate

Abstract

In a meta-analysis published by myself and co-authors, we report differences in the life history risk factors for estrogen receptor negative (ER-) and estrogen receptor positive (ER+) breast cancers. Our meta-analysis did not find the association of ER- breast cancer risk with fast life history characteristics that Hidaka and Boddy suggest in their response to our article. There are a number of possible explanations for the differences between their conclusions and the conclusions we drew from our meta-analysis, including limitations of our meta-analysis and methodological challenges in measuring and categorizing estrogen receptor status. These challenges, along with the association of ER+ breast cancer with slow life history characteristics, may make it challenging to find a clear signal of ER- breast cancer with fast life history characteristics, even if that relationship does exist. The contradictory results regarding breast cancer risk and life history characteristics illustrate a more general challenge in evolutionary medicine: often different sub-theories in evolutionary biology make contradictory predictions about disease risk. In this case, life history models predict that breast cancer risk should increase with faster life history characteristics, while the evolutionary mismatch hypothesis predicts that breast cancer risk should increase with delayed reproduction. Whether life history tradeoffs contribute to ER- breast cancer is still an open question, but current models and several lines of evidence suggest that it is a possibility.

Original languageEnglish (US)
Pages (from-to)177-179
Number of pages3
JournalEvolution, Medicine and Public Health
Volume2016
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

life history theory
Estrogen Receptors
breast neoplasms
life history
Breast Neoplasms
meta-analysis
Meta-Analysis
cancer
cancer risk
estrogen receptors
Life History Traits
evolutionary biology
risk factor
medicine
Reproduction
risk factors
Medicine
Biological Sciences
prediction

Keywords

  • Cancer susceptibility
  • Evolutionary mismatch
  • Life history theory
  • Tradeoffs

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Health, Toxicology and Mutagenesis
  • Medicine (miscellaneous)

Cite this

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title = "Life history theory and breast cancer risk: Methodological and theoretical challenges: Response to {"}Is estrogen receptor negative breast cancer risk associated with a fast life history strategy{"}?",
abstract = "In a meta-analysis published by myself and co-authors, we report differences in the life history risk factors for estrogen receptor negative (ER-) and estrogen receptor positive (ER+) breast cancers. Our meta-analysis did not find the association of ER- breast cancer risk with fast life history characteristics that Hidaka and Boddy suggest in their response to our article. There are a number of possible explanations for the differences between their conclusions and the conclusions we drew from our meta-analysis, including limitations of our meta-analysis and methodological challenges in measuring and categorizing estrogen receptor status. These challenges, along with the association of ER+ breast cancer with slow life history characteristics, may make it challenging to find a clear signal of ER- breast cancer with fast life history characteristics, even if that relationship does exist. The contradictory results regarding breast cancer risk and life history characteristics illustrate a more general challenge in evolutionary medicine: often different sub-theories in evolutionary biology make contradictory predictions about disease risk. In this case, life history models predict that breast cancer risk should increase with faster life history characteristics, while the evolutionary mismatch hypothesis predicts that breast cancer risk should increase with delayed reproduction. Whether life history tradeoffs contribute to ER- breast cancer is still an open question, but current models and several lines of evidence suggest that it is a possibility.",
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