Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

Jeffrey H. Kordower, Yaping Chu, Robert A. Hauser, Thomas B. Freeman, C. Warren Olanow

Research output: Contribution to journalArticlepeer-review

1124 Scopus citations

Abstract

Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body-like inclusions that stained positively for α-synuclein and ubiquitin and to have reduced immunostaining for dopamine transporter. These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)504-506
Number of pages3
JournalNature Medicine
Volume14
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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