Learning-dependent dendritic hypertrophy of cerebellar stellate cells: Plasticity of local circuit neurons

Jeffrey A. Kleim, Rodney A. Swain, Cheryl M. Czerlanis, Jennifer L. Kelly, Michelle A. Pipitone, William T. Greenough

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Recent work has shown that motor learning, but not mere motor activity, changes the morphology of Purkinje cells, the major projection neurons of the cerebellar cortex. In the present study we examined how motor skill learning affects the dendritic morphology of the stellate local circuit neurons. Adult female rats were either trained to complete a complex motor learning task or forced to traverse a flat, obstacle-free runway. Golgi impregnated stellate cells were then traced via camera lucida and their dendritic arborizations examined with a concentric ring analysis. Results showed the motor learning animals to have significantly greater stellate cell dendritic arborizations than the activity controls. Thus these local circuit neurons exhibit morphological plasticity.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalNeurobiology of Learning and Memory
Volume67
Issue number1
DOIs
StatePublished - Jan 1997
Externally publishedYes

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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