TY - JOUR
T1 - Learning-dependent dendritic hypertrophy of cerebellar stellate cells
T2 - Plasticity of local circuit neurons
AU - Kleim, Jeffrey A.
AU - Swain, Rodney A.
AU - Czerlanis, Cheryl M.
AU - Kelly, Jennifer L.
AU - Pipitone, Michelle A.
AU - Greenough, William T.
N1 - Funding Information:
1We thank Jared Lambert and Andrea Birnbaum for their assistance with training the animals. This work was supported by AG10154, MH35321, the Retirement Research Foundation, and an NSERC fellowship. Address correspondence and reprint requests to William T. Greenough. Fax: (217) 244-5180. E-mail: wgreenou@psych.uiuc.edu.
PY - 1997/1
Y1 - 1997/1
N2 - Recent work has shown that motor learning, but not mere motor activity, changes the morphology of Purkinje cells, the major projection neurons of the cerebellar cortex. In the present study we examined how motor skill learning affects the dendritic morphology of the stellate local circuit neurons. Adult female rats were either trained to complete a complex motor learning task or forced to traverse a flat, obstacle-free runway. Golgi impregnated stellate cells were then traced via camera lucida and their dendritic arborizations examined with a concentric ring analysis. Results showed the motor learning animals to have significantly greater stellate cell dendritic arborizations than the activity controls. Thus these local circuit neurons exhibit morphological plasticity.
AB - Recent work has shown that motor learning, but not mere motor activity, changes the morphology of Purkinje cells, the major projection neurons of the cerebellar cortex. In the present study we examined how motor skill learning affects the dendritic morphology of the stellate local circuit neurons. Adult female rats were either trained to complete a complex motor learning task or forced to traverse a flat, obstacle-free runway. Golgi impregnated stellate cells were then traced via camera lucida and their dendritic arborizations examined with a concentric ring analysis. Results showed the motor learning animals to have significantly greater stellate cell dendritic arborizations than the activity controls. Thus these local circuit neurons exhibit morphological plasticity.
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U2 - 10.1006/nlme.1996.3742
DO - 10.1006/nlme.1996.3742
M3 - Article
C2 - 9013498
AN - SCOPUS:0030863970
SN - 1074-7427
VL - 67
SP - 29
EP - 33
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
IS - 1
ER -