Late effects of hematopoietic cell transplantation among 10-year adult survivors compared with case-matched controls

Karen L. Syrjala, Shelby Langer, Janet R. Abrams, Barry E. Storer, Paul J. Martin

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

Purpose: To determine late effects of hematopoietic cell transplantation (HCT) on health problems and health-related quality of life for 10-year survivors. Patients and Methods: Four hundred five adults consented to the study before HCT. Medical records and standardized self-report measures were maintained prospectively. After 10 years, 137 survivors and nontransplant controls, case-matched on age, sex, and race, completed self-report of medical problems, symptoms, and health-related quality of life. Results: Survivors and controls had similar rates of hospitalization and most diseases, but survivors reported an average of 3.5 medical problems versus 1.7 for controls (P < .001). Survivors reported more musculoskeletal stiffness, cramps, weakness and joint swelling (P < .001), cataract surgery (P < .001), hepatitis C (P = .004), sexual problems for men (P = .01) and women (P < .001), restrictions in social function (P = .002), memory and attention concerns (P = .003), urinary frequency or leaking (P = .006), use of psychotropic medication (P = .009), and denial of life and health insurance (P < .001). Survivors and controls did not differ in self-reported rates of osteoporosis, hypothyroidism, employment, marital satisfaction, divorce, or psychological health. Conclusion: Although indistinguishable in many respects, survivors had more medical needs than controls. Health problems were not focused on specific diseases or limited to survivors with readily identifiable risk factors. Musculoskeletal problems require both screening and research into etiologies and effective treatments. Osteoporosis and hypothyroidism may be underdiagnosed. Survivors require screening for sexual problems, urinary frequency, mood and need for antidepressants or benzodiazepines.

Original languageEnglish (US)
Pages (from-to)6596-6606
Number of pages11
JournalJournal of Clinical Oncology
Volume23
Issue number27
DOIs
StatePublished - Sep 20 2005
Externally publishedYes

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Cell Transplantation
Survivors
Hypothyroidism
Self Report
Osteoporosis
Health
Quality of Life
Life Insurance
Muscle Cramp
Divorce
Health Insurance
Hepatitis C
Benzodiazepines
Cataract
Antidepressive Agents
Medical Records
Hospitalization
Joints
Psychology

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Late effects of hematopoietic cell transplantation among 10-year adult survivors compared with case-matched controls. / Syrjala, Karen L.; Langer, Shelby; Abrams, Janet R.; Storer, Barry E.; Martin, Paul J.

In: Journal of Clinical Oncology, Vol. 23, No. 27, 20.09.2005, p. 6596-6606.

Research output: Contribution to journalArticle

Syrjala, Karen L. ; Langer, Shelby ; Abrams, Janet R. ; Storer, Barry E. ; Martin, Paul J. / Late effects of hematopoietic cell transplantation among 10-year adult survivors compared with case-matched controls. In: Journal of Clinical Oncology. 2005 ; Vol. 23, No. 27. pp. 6596-6606.
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