Laser-induced Fluorescence Spectroscopy (LFS): Detection of unstable thrombogenic atherosclerotic plaque formation in a rabbit model - A first look diagnostic approach

Alexander Christov; Erbin Dai; Maria Drangova; Liying Liu; George S. Abela; Piers Nash; Grant McFadden; Alexandra Lucas

doi:10.1117/12.409329

Laser-induced Fluorescence Spectroscopy (LFS): Detection of unstable thrombogenic atherosclerotic plaque formation in a rabbit model - A first look diagnostic approach

Alexander Christov, Erbin Dai, Maria Drangova, Liying Liu, George S. Abela, Piers Nash, Grant McFadden, Alexandra Lucas

Research output: Contribution to journal › Article › peer-review

Abstract

Many approaches to imaging of unstable plaque have been applied to detect vascular thrombosis and occlusion with only moderate success. LFS detected significant and specific changes in thrombogenic plaque in a rabbit model. Fluorescence emission intensity analysis of structural characteristics may provide an optical diagnostic technique for early recognition of unstable coronary syndromes.

Original language	English (US)
Pages (from-to)	190-201
Number of pages	12
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4161
DOIs	https://doi.org/10.1117/12.409329
State	Published - Jan 1 2000
Externally published	Yes

Keywords

Atherosclerosis
Fluorescence emission
Plaque disruption
Plaque instability
Thrombosis
Vulnerable plaque

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.409329

Cite this

Christov, A., Dai, E., Drangova, M., Liu, L., Abela, G. S., Nash, P., McFadden, G., & Lucas, A. (2000). Laser-induced Fluorescence Spectroscopy (LFS): Detection of unstable thrombogenic atherosclerotic plaque formation in a rabbit model - A first look diagnostic approach. Proceedings of SPIE - The International Society for Optical Engineering, 4161, 190-201. https://doi.org/10.1117/12.409329

Laser-induced Fluorescence Spectroscopy (LFS): Detection of unstable thrombogenic atherosclerotic plaque formation in a rabbit model - A first look diagnostic approach. / Christov, Alexander; Dai, Erbin; Drangova, Maria et al.
In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 4161, 01.01.2000, p. 190-201.

Research output: Contribution to journal › Article › peer-review

Christov, A, Dai, E, Drangova, M, Liu, L, Abela, GS, Nash, P, McFadden, G & Lucas, A 2000, 'Laser-induced Fluorescence Spectroscopy (LFS): Detection of unstable thrombogenic atherosclerotic plaque formation in a rabbit model - A first look diagnostic approach', Proceedings of SPIE - The International Society for Optical Engineering, vol. 4161, pp. 190-201. https://doi.org/10.1117/12.409329

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keywords = "Atherosclerosis, Fluorescence emission, Plaque disruption, Plaque instability, Thrombosis, Vulnerable plaque",

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AU - Nash, Piers

AU - McFadden, Grant

AU - Lucas, Alexandra

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KW - Fluorescence emission

KW - Plaque disruption

KW - Plaque instability

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Laser-induced Fluorescence Spectroscopy (LFS): Detection of unstable thrombogenic atherosclerotic plaque formation in a rabbit model - A first look diagnostic approach

Abstract

Keywords

ASJC Scopus subject areas

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