Laser-induced Fluorescence Spectroscopy (LFS): Detection of unstable thrombogenic atherosclerotic plaque formation in a rabbit model - A first look diagnostic approach

Alexander Christov, Erbin Dai, Maria Drangova, Liying Liu, George S. Abela, Piers Nash, Grant McFadden, Alexandra Lucas

Research output: Contribution to journalArticlepeer-review

Abstract

Many approaches to imaging of unstable plaque have been applied to detect vascular thrombosis and occlusion with only moderate success. LFS detected significant and specific changes in thrombogenic plaque in a rabbit model. Fluorescence emission intensity analysis of structural characteristics may provide an optical diagnostic technique for early recognition of unstable coronary syndromes.

Original languageEnglish (US)
Pages (from-to)190-201
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4161
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Atherosclerosis
  • Fluorescence emission
  • Plaque disruption
  • Plaque instability
  • Thrombosis
  • Vulnerable plaque

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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