TY - JOUR
T1 - Laser-induced fluorescence in malignant and normal tissue in mice injected with two different carotenoporphyrins
AU - Nilsson, H.
AU - Johansson, J.
AU - Svanberg, K.
AU - Svanberg, S.
AU - Jori, G.
AU - Reddi, E.
AU - Segalla, A.
AU - Gust, D.
AU - Moore, Ana
AU - Moore, Thomas
N1 - Funding Information:
This work was supported by the Swedish Cancer Society, the Swedish Board for Technical and Industrial Develpment and the Swedish Research Council of En ring Sciences.
PY - 1994/11
Y1 - 1994/11
N2 - Laser-induced fluorescence (LIF) was used to characterise the localisation of an intravenously administered trimethylated carotenoporphyrin [CP(Me)3] and a trimethoxylated carotenoporphyrin [CP(OMe)3] in an intramuscularly transplanted malignant tumour (MS-2 fibrosarcoma) and healthy muscle in female Balb/c mice, 3, 24, 48 and 96 h post injection. The fluorescence was induced with a dye laser pumped by a nitrogen laser, emitting light at 425 nm. The fluorescence spectra were recorded in the region 455-760 nm using a polychromator equipped with an image-intensified CCD camera. The tumour/peritumoral muscle ratio was about 5:1 for CP(Me)3 and about 6:1 for CP(OMe)3 in terms of the background-free fluorescence intensity, which peaked at about 655 nm. By including the endogenous tissue fluorescence, the contrast was further enhanced by a factor of approximately 2.
AB - Laser-induced fluorescence (LIF) was used to characterise the localisation of an intravenously administered trimethylated carotenoporphyrin [CP(Me)3] and a trimethoxylated carotenoporphyrin [CP(OMe)3] in an intramuscularly transplanted malignant tumour (MS-2 fibrosarcoma) and healthy muscle in female Balb/c mice, 3, 24, 48 and 96 h post injection. The fluorescence was induced with a dye laser pumped by a nitrogen laser, emitting light at 425 nm. The fluorescence spectra were recorded in the region 455-760 nm using a polychromator equipped with an image-intensified CCD camera. The tumour/peritumoral muscle ratio was about 5:1 for CP(Me)3 and about 6:1 for CP(OMe)3 in terms of the background-free fluorescence intensity, which peaked at about 655 nm. By including the endogenous tissue fluorescence, the contrast was further enhanced by a factor of approximately 2.
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U2 - 10.1038/bjc.1994.413
DO - 10.1038/bjc.1994.413
M3 - Article
C2 - 7947092
AN - SCOPUS:0028154913
SN - 0007-0920
VL - 70
SP - 873
EP - 879
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 5
ER -