Laser Ablation/Ionization and Mass Spectrometric Analysis of Massive Polymers

Randall Nelson (Inventor), Peter Williams (Inventor)

Research output: Patent


The determination of the molecular weights and structures of large biological molecules such as peptides, proteins or nucleic acids has, for a long time, been the object of much research in terms of finding faster and more effective methods. Such determinations are generally accomplished through techniques such as gel electrophoresis or by selective fragmentation with enzymes, or through mass spectrometry, etc. Researchers at Arizona State University have develoiped a technique for volatizing and ionizing large biomolecules, including peptides, proteins, nucleic acids and oligosaccharidesl, for mass spectrometry. Volatization occurs by pulsed laser ablation of frozen aqueous solutions. Ionization is enhanced by tuning the laser to a resonant electronic transition of either a solution component, e.g., sodium, or a substrate atom. More detail describing the present invention can be found in US Patent No. 5,135,870.
Original languageEnglish (US)
StatePublished - Jan 1 1900


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