Large-scale pedigree analysis leads to evidence for founder effects of hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta)

Sreetharan Kanthaswamy, Rachel Reader, Ross Tarara, Karen Oslund, Mark Allen, Jillian Ng, Chloe Grinberg, Dallas Hyde, David G. Smith, Nicholas Lerche

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Hypertrophic cardiomyopathy (HCM) is the abnormal thickening of the ventricles and an increase in cardiac mass. Methods: Pedigree analyses involving 108 rhesus macaques with pronounced HCM were performed. Results: Analyses revealed a strong genetic predisposition to this disease. Conclusions: Macaques are ideal for investigating HCM because of their marked similarity to humans genetically, physiologically, and anatomically.

Original languageEnglish (US)
Pages (from-to)288-291
Number of pages4
JournalJournal of Medical Primatology
Volume43
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Founder Effect
Hypertrophic Cardiomyopathy
cardiomyopathy
founder effect
Pedigree
Macaca mulatta
pedigree
Macaca
Genetic Predisposition to Disease
methodology

Keywords

  • Genetic disease
  • Heart disease
  • Left ventricular hypertrophy
  • Non-human primates

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Large-scale pedigree analysis leads to evidence for founder effects of hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta). / Kanthaswamy, Sreetharan; Reader, Rachel; Tarara, Ross; Oslund, Karen; Allen, Mark; Ng, Jillian; Grinberg, Chloe; Hyde, Dallas; Smith, David G.; Lerche, Nicholas.

In: Journal of Medical Primatology, Vol. 43, No. 4, 2014, p. 288-291.

Research output: Contribution to journalArticle

Kanthaswamy, Sreetharan ; Reader, Rachel ; Tarara, Ross ; Oslund, Karen ; Allen, Mark ; Ng, Jillian ; Grinberg, Chloe ; Hyde, Dallas ; Smith, David G. ; Lerche, Nicholas. / Large-scale pedigree analysis leads to evidence for founder effects of hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta). In: Journal of Medical Primatology. 2014 ; Vol. 43, No. 4. pp. 288-291.
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AU - Allen, Mark

AU - Ng, Jillian

AU - Grinberg, Chloe

AU - Hyde, Dallas

AU - Smith, David G.

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