Abstract
Background: Hypertrophic cardiomyopathy (HCM) is the abnormal thickening of the ventricles and an increase in cardiac mass. Methods: Pedigree analyses involving 108 rhesus macaques with pronounced HCM were performed. Results: Analyses revealed a strong genetic predisposition to this disease. Conclusions: Macaques are ideal for investigating HCM because of their marked similarity to humans genetically, physiologically, and anatomically.
Original language | English (US) |
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Pages (from-to) | 288-291 |
Number of pages | 4 |
Journal | Journal of Medical Primatology |
Volume | 43 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2014 |
Externally published | Yes |
Keywords
- Genetic disease
- Heart disease
- Left ventricular hypertrophy
- Non-human primates
ASJC Scopus subject areas
- Animal Science and Zoology
- General Veterinary