Our research is focused at coupling to the implementation of Nucleic Acid Programmable Protein Array (NAPPA) technology to real-time label-free SPR-based detection. Here, we show the combination of both technologies that together could lead to the ability to measure binding events in real-time for many protein interactions simultaneously using a label-free technology. This could revolutionize the study of protein interactions networks by enabling quantitative comparisons of binding affinities across many molecular species, as well determining the kinetics rates of binding and release.
|Original language||English (US)|
|Title of host publication||Functional Proteomics and Nanotechnology-Based Microarrays|
|Publisher||Pan Stanford Publishing Pte. Ltd.|
|Number of pages||17|
|State||Published - Jun 1 2010|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)