Label-free detection of NAPPA: Surface plasmon resonance

Manuel Fuentes, Sanjeeva Svrivastava, Nirosahan Ramachandran, Eugenie Hainsworth, Josh LaBaer

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Our research is focused at coupling to the implementation of Nucleic Acid Programmable Protein Array (NAPPA) technology to real-time label-free SPR-based detection. Here, we show the combination of both technologies that together could lead to the ability to measure binding events in real-time for many protein interactions simultaneously using a label-free technology. This could revolutionize the study of protein interactions networks by enabling quantitative comparisons of binding affinities across many molecular species, as well determining the kinetics rates of binding and release.

Original languageEnglish (US)
Title of host publicationFunctional Proteomics and Nanotechnology-Based Microarrays
PublisherPan Stanford Publishing Pte. Ltd.
Pages287-303
Number of pages17
ISBN (Print)9789814267762
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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