Krüppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1

Sun Hee Kim, Yun Yong Park, Sung Nam Cho, Ofer Margalit, Dingzhi Wang, Raymond N. Dubois

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.

Original languageEnglish (US)
Article numbere0159899
JournalPLoS One
Volume11
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

Early Growth Response Protein 1
colorectal neoplasms
Colorectal Neoplasms
stomach neoplasms
Growth
adenocarcinoma
prognosis
Stomach Neoplasms
Tumors
Adenocarcinoma
Transcription Factors
transcription factors
proteins
kidneys
Kidney
therapeutics
neoplasms
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Kim, S. H., Park, Y. Y., Cho, S. N., Margalit, O., Wang, D., & Dubois, R. N. (2016). Krüppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1. PLoS One, 11(7), [e0159899]. https://doi.org/10.1371/journal.pone.0159899

Krüppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1. / Kim, Sun Hee; Park, Yun Yong; Cho, Sung Nam; Margalit, Ofer; Wang, Dingzhi; Dubois, Raymond N.

In: PLoS One, Vol. 11, No. 7, e0159899, 01.07.2016.

Research output: Contribution to journalArticle

Kim, SH, Park, YY, Cho, SN, Margalit, O, Wang, D & Dubois, RN 2016, 'Krüppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1', PLoS One, vol. 11, no. 7, e0159899. https://doi.org/10.1371/journal.pone.0159899
Kim, Sun Hee ; Park, Yun Yong ; Cho, Sung Nam ; Margalit, Ofer ; Wang, Dingzhi ; Dubois, Raymond N. / Krüppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1. In: PLoS One. 2016 ; Vol. 11, No. 7.
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