Krüppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1

Sun Hee Kim; Yun Yong Park; Sung Nam Cho; Ofer Margalit; Dingzhi Wang; Raymond N. Dubois

doi:10.1371/journal.pone.0159899

Krüppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1

Sun Hee Kim, Yun Yong Park, Sung Nam Cho, Ofer Margalit, Dingzhi Wang, Raymond N. Dubois

Biodesign Institute

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.

Original language	English (US)
Article number	e0159899
Journal	PloS one
Volume	11
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0159899
State	Published - Jul 1 2016

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abstract = "Kr{\"u}ppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.",

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AU - Kim, Sun Hee

AU - Park, Yun Yong

AU - Cho, Sung Nam

AU - Margalit, Ofer

AU - Wang, Dingzhi

AU - Dubois, Raymond N.

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N2 - Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.

AB - Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.

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Krüppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1

Abstract

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