TY - JOUR
T1 - Known unknowns of cardiolipin signaling
T2 - The best is yet to come
AU - Maguire, John J.
AU - Tyurina, Yulia Y.
AU - Mohammadyani, Dariush
AU - Kapralov, Aleksandr A.
AU - Anthonymuthu, Tamil S.
AU - Qu, Feng
AU - Amoscato, Andrew A.
AU - Sparvero, Louis J.
AU - Tyurin, Vladimir A.
AU - Planas-Iglesias, Joan
AU - He, Rong Rong
AU - Klein-Seetharaman, Judith
AU - Bayır, Hülya
AU - Kagan, Valerian E.
N1 - Funding Information:
This study was supported by National Institutes of Health : PO1HL114453 , CA165065 , ES020693 , U19AIO68021 , NS076511 , NS061817 ; National Institute for Occupational Safety and Health : OH008282 , Human Frontier Science Program HFSP-RGP00132014 , the Barth Syndrome Foundation, Inc. and the Barth Syndrome Foundation of Canada .
Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Since its discovery 75 years ago, a wealth of knowledge has accumulated on the role of cardiolipin, the hallmark phospholipid of mitochondria, in bioenergetics and particularly on the structural organization of the inner mitochondrial membrane. A surge of interest in this anionic doubly-charged tetra-acylated lipid found in both prokaryotes and mitochondria has emerged based on its newly discovered signaling functions. Cardiolipin displays organ, tissue, cellular and transmembrane distribution asymmetries. A collapse of the membrane asymmetry represents a pro-mitophageal mechanism whereby externalized cardiolipin acts as an “eat-me” signal. Oxidation of cardiolipin's polyunsaturated acyl chains - catalyzed by cardiolipin complexes with cytochrome c. - is a pro-apoptotic signal. The messaging functions of myriads of cardiolipin species and their oxidation products are now being recognized as important intracellular and extracellular signals for innate and adaptive immune systems. This newly developing field of research exploring cardiolipin signaling is the main subject of this review. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
AB - Since its discovery 75 years ago, a wealth of knowledge has accumulated on the role of cardiolipin, the hallmark phospholipid of mitochondria, in bioenergetics and particularly on the structural organization of the inner mitochondrial membrane. A surge of interest in this anionic doubly-charged tetra-acylated lipid found in both prokaryotes and mitochondria has emerged based on its newly discovered signaling functions. Cardiolipin displays organ, tissue, cellular and transmembrane distribution asymmetries. A collapse of the membrane asymmetry represents a pro-mitophageal mechanism whereby externalized cardiolipin acts as an “eat-me” signal. Oxidation of cardiolipin's polyunsaturated acyl chains - catalyzed by cardiolipin complexes with cytochrome c. - is a pro-apoptotic signal. The messaging functions of myriads of cardiolipin species and their oxidation products are now being recognized as important intracellular and extracellular signals for innate and adaptive immune systems. This newly developing field of research exploring cardiolipin signaling is the main subject of this review. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum.
KW - Apoptosis
KW - Cardiolipin oxidation
KW - Cardiolipin signaling
KW - Innate and adaptive immunity
KW - Mitophagy
KW - Peroxidase
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U2 - 10.1016/j.bbalip.2016.08.001
DO - 10.1016/j.bbalip.2016.08.001
M3 - Article
C2 - 27498292
AN - SCOPUS:84995482168
SN - 1388-1981
VL - 1862
SP - 8
EP - 24
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
IS - 1
ER -