Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats via oral administration

Ya Tao Du, Xuan Wang, Xiao Dong Wu, Wei Xi Tian

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The inhibitory effects of a black tea extract on fatty acid synthase were measured through inhibition kinetics. The Keemun black tea extract showed more potent inhibitory activity on fatty acid synthase than green tea extract. Additionally, the inhibitory ability of the black tea extract depended on the extracting solvent and the conditions used. Only 10-23% of the inhibitory activity from the black tea was extracted by the general method of boiling with water. The results suggested that the main fatty acid synthase inhibitors in black tea might be theaflavins. Which were more potent than epigallocatechin gallate or C75. The reaction site on the fatty acid synthase and the inhibition kinetics for the extract were different from those of epigallocatechin gallate or C75. In addition, Keemun black tea extract significantly reduced food intake, body weight and blood triglyceride of diet-induced obesity SD rats via oral administration.

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume20
Issue number4
DOIs
StatePublished - Aug 1 2005
Externally publishedYes

Keywords

  • Black tea
  • Body weight
  • Fatty acid synthase
  • Food intake
  • Inhibitor
  • Theaflavins

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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