A new cell growth inhibitory (PS ED502.2 μg/mL) phenanthraquinone designated combretastatin C-l (2) has been isolated from the African tree Combretum caffrum. The structure (2) assigned combretastatin C-l was based on high-resolution mass and NMR spectral analyses and confirmed by total syntheses. Synthetic routes 5b → 6b → 2 and especially 5c → 6c → 2 proved to be quite practical.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of Organic Chemistry|
|State||Published - Aug 1 1989|
ASJC Scopus subject areas
- Organic Chemistry