A new cell growth inhibitory (PS ED502.2 μg/mL) phenanthraquinone designated combretastatin C-l (2) has been isolated from the African tree Combretum caffrum. The structure (2) assigned combretastatin C-l was based on high-resolution mass and NMR spectral analyses and confirmed by total syntheses. Synthetic routes 5b → 6b → 2 and especially 5c → 6c → 2 proved to be quite practical.
ASJC Scopus subject areas
- Organic Chemistry