Isolation, Structure, and Synthesis of Combretastatin C-l

Sheo Bux Singh; George Pettit

doi:10.1021/jo00278a023

Isolation, Structure, and Synthesis of Combretastatin C-l

Sheo Bux Singh, George Pettit

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Abstract

A new cell growth inhibitory (PS ED₅₀2.2 μg/mL) phenanthraquinone designated combretastatin C-l (2) has been isolated from the African tree Combretum caffrum. The structure (2) assigned combretastatin C-l was based on high-resolution mass and NMR spectral analyses and confirmed by total syntheses. Synthetic routes 5b → 6b → 2 and especially 5c → 6c → 2 proved to be quite practical.

Original language	English (US)
Pages (from-to)	4105-4114
Number of pages	10
Journal	Journal of Organic Chemistry
Volume	54
Issue number	17
DOIs	https://doi.org/10.1021/jo00278a023
State	Published - Aug 1 1989

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo00278a023

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title = "Isolation, Structure, and Synthesis of Combretastatin C-l",

abstract = "A new cell growth inhibitory (PS ED502.2 μg/mL) phenanthraquinone designated combretastatin C-l (2) has been isolated from the African tree Combretum caffrum. The structure (2) assigned combretastatin C-l was based on high-resolution mass and NMR spectral analyses and confirmed by total syntheses. Synthetic routes 5b → 6b → 2 and especially 5c → 6c → 2 proved to be quite practical.",

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AB - A new cell growth inhibitory (PS ED502.2 μg/mL) phenanthraquinone designated combretastatin C-l (2) has been isolated from the African tree Combretum caffrum. The structure (2) assigned combretastatin C-l was based on high-resolution mass and NMR spectral analyses and confirmed by total syntheses. Synthetic routes 5b → 6b → 2 and especially 5c → 6c → 2 proved to be quite practical.

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Isolation, Structure, and Synthesis of Combretastatin C-l

Abstract

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