Isolation of geodiastatins 1 and 2 from the marine sponge geodia mesotriaena

George Pettit, John A. Rideout, Julia A. Hasler

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

An aqueous extract of the Gulf of California Geodia mesotriaena von Lendenfeld (Porifera) has been found to contain two chromoprotein antineoplastic agents designated geodiastatins 1 and 2. The active brownish-black proteins from this siliceous sponge were found to contain major (>1%) amounts of silicon and to inhibit growth of the murine P388 lymphocytic leukemia. A related protein (geodiatoxin 1) was found to be toxic at 6 mg/kg (LD100, mouse).

Original languageEnglish (US)
Pages (from-to)588-592
Number of pages5
JournalJournal of Natural Products
Volume44
Issue number5
DOIs
StatePublished - Sep 1981

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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