Isolation of geodiastatins 1 and 2 from the marine sponge Geodia mesotriaena

George Pettit, John A. Rideout, Julia A. Hasler

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

An aqueous extract of the Gulf of California Geodia mesotriaena von Lendenfeld (Porifera) has been found to contain two chromoprotein antineoplastic agents designated geodiastatins 1 and 2. The active brownish-black proteins from this siliceous sponge were found to contain major (>1%) amounts of silicon and to inhibit growth of the murine P388 lymphocytic leukemia. A related protein (geodia-toxin 1) was found to be toxic at 6 mg/kg (LD100, mouse).

Original languageEnglish (US)
Pages (from-to)588-592
Number of pages5
JournalJournal of Natural Products
Volume44
Issue number5
StatePublished - 1981

Fingerprint

Geodia
Porifera
Lymphoid Leukemia
lymphocytic leukemia
antineoplastic agents
Poisons
Gulf of California
mice
Silicon
silicon
Antineoplastic Agents
Proteins
toxins
proteins
extracts
Growth
water
geodiastatins

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Isolation of geodiastatins 1 and 2 from the marine sponge Geodia mesotriaena. / Pettit, George; Rideout, John A.; Hasler, Julia A.

In: Journal of Natural Products, Vol. 44, No. 5, 1981, p. 588-592.

Research output: Contribution to journalArticle

Pettit, George ; Rideout, John A. ; Hasler, Julia A. / Isolation of geodiastatins 1 and 2 from the marine sponge Geodia mesotriaena. In: Journal of Natural Products. 1981 ; Vol. 44, No. 5. pp. 588-592.
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