Isolation of geodiastatins 1 and 2 from the marine sponge geodia mesotriaena

George Pettit; John A. Rideout; Julia A. Hasler

doi:10.1021/np50017a015

Isolation of geodiastatins 1 and 2 from the marine sponge geodia mesotriaena

George Pettit, John A. Rideout, Julia A. Hasler

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18 Scopus citations

Abstract

An aqueous extract of the Gulf of California Geodia mesotriaena von Lendenfeld (Porifera) has been found to contain two chromoprotein antineoplastic agents designated geodiastatins 1 and 2. The active brownish-black proteins from this siliceous sponge were found to contain major (>1%) amounts of silicon and to inhibit growth of the murine P388 lymphocytic leukemia. A related protein (geodiatoxin 1) was found to be toxic at 6 mg/kg (LD100, mouse).

Original language	English (US)
Pages (from-to)	588-592
Number of pages	5
Journal	Journal of Natural Products
Volume	44
Issue number	5
DOIs	https://doi.org/10.1021/np50017a015
State	Published - Sep 1981

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50017a015

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abstract = "An aqueous extract of the Gulf of California Geodia mesotriaena von Lendenfeld (Porifera) has been found to contain two chromoprotein antineoplastic agents designated geodiastatins 1 and 2. The active brownish-black proteins from this siliceous sponge were found to contain major (>1%) amounts of silicon and to inhibit growth of the murine P388 lymphocytic leukemia. A related protein (geodiatoxin 1) was found to be toxic at 6 mg/kg (LD100, mouse).",

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AU - Hasler, Julia A.

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AB - An aqueous extract of the Gulf of California Geodia mesotriaena von Lendenfeld (Porifera) has been found to contain two chromoprotein antineoplastic agents designated geodiastatins 1 and 2. The active brownish-black proteins from this siliceous sponge were found to contain major (>1%) amounts of silicon and to inhibit growth of the murine P388 lymphocytic leukemia. A related protein (geodiatoxin 1) was found to be toxic at 6 mg/kg (LD100, mouse).

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Isolation of geodiastatins 1 and 2 from the marine sponge geodia mesotriaena

Abstract

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