Isolation and X-ray crystal structure of racemic xestospongin D from the Singapore marine sponge Niphates SP1

George Pettit, Brian Orr, Delbert L. Herald, Dennis L. Doubek, Larry Tackett, Jean M. Schmidt, Michael R. Boyd, Robin Pettit, John H A Hooper

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

(±)-Xestospongin D (2) has been isolated from the Singapore marine sponge Niphates sp. The natural product was found to be racemic in contrast to earlier isolations of (+)-xestospongin D from Xestospongia and Haliclona species. The (±)-xestospongin D was found to inhibit growth of certain human cancer cell lines comprising the NCI panel (e.g., leukemia subpanel, mean GI50 3.62 ± 2.02 × 10-6M; breast subpanel, mean GI50 4.53 ± 1.98 × 10-6M) as well as the marine P388 lymphocytic leukemia (ED50 1.7 μg/mL) and the bacterium Hicrococcus luceus.

Original languageEnglish (US)
Pages (from-to)1313-1318
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number12
DOIs
StatePublished - Jun 18 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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