Abstract
(±)-Xestospongin D (2) has been isolated from the Singapore marine sponge Niphates sp. The natural product was found to be racemic in contrast to earlier isolations of (+)-xestospongin D from Xestospongia and Haliclona species. The (±)-xestospongin D was found to inhibit growth of certain human cancer cell lines comprising the NCI panel (e.g., leukemia subpanel, mean GI50 3.62 ± 2.02 × 10-6M; breast subpanel, mean GI50 4.53 ± 1.98 × 10-6M) as well as the marine P388 lymphocytic leukemia (ED50 1.7 μg/mL) and the bacterium Hicrococcus luceus.
Original language | English (US) |
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Pages (from-to) | 1313-1318 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 6 |
Issue number | 12 |
DOIs | |
State | Published - Jun 18 1996 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry