Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel(1)

George Pettit; Yuping Tang; Qingwen Zhang; Gregory T. Bourne; Christoph A. Arm; John E. Leet; John C. Knight; Robin Pettit; Jean Chapuis; Dennis L. Doubek; Franklin J. Ward; Christine Weber; John N A Hooper

doi:10.1021/np300828y

Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel(1)

George Pettit, Yuping Tang, Qingwen Zhang, Gregory T. Bourne, Christoph A. Arm, John E. Leet, John C. Knight, Robin Pettit, Jean Chapuis, Dennis L. Doubek, Franklin J. Ward, Christine Weber, John N A Hooper

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Abstract

An investigation begun in 1979 directed at the Republic of Palau marine sponge Agelas axifera Hentschel for cancer cell growth inhibitory constituents subsequently led to the isolation of three new pyrimidine diterpenes designated axistatins 1 (1), 2 (2), and 3 (3), together with the previously reported formamides 4, 5, and agelasine F (6). The structures were elucidated by analysis of 2D-NMR spectra and by HRMS. All of the isolated compounds were found to be moderate inhibitors of cancer cell growth. Axistatins 1-3 (1-3), formamide 4, and agelasine F (6) also exhibited antimicrobial activity.

Original language	English (US)
Pages (from-to)	420-424
Number of pages	5
Journal	Journal of Natural Products
Volume	76
Issue number	3
DOIs	https://doi.org/10.1021/np300828y
State	Published - Mar 22 2013

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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Pettit, G., Tang, Y., Zhang, Q., Bourne, G. T., Arm, C. A., Leet, J. E., Knight, J. C., Pettit, R., Chapuis, J., Doubek, D. L., Ward, F. J., Weber, C., & Hooper, J. N. A. (2013). Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel(1). Journal of Natural Products, 76(3), 420-424. https://doi.org/10.1021/np300828y

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abstract = "An investigation begun in 1979 directed at the Republic of Palau marine sponge Agelas axifera Hentschel for cancer cell growth inhibitory constituents subsequently led to the isolation of three new pyrimidine diterpenes designated axistatins 1 (1), 2 (2), and 3 (3), together with the previously reported formamides 4, 5, and agelasine F (6). The structures were elucidated by analysis of 2D-NMR spectra and by HRMS. All of the isolated compounds were found to be moderate inhibitors of cancer cell growth. Axistatins 1-3 (1-3), formamide 4, and agelasine F (6) also exhibited antimicrobial activity.",

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AU - Pettit, George

AU - Tang, Yuping

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AU - Bourne, Gregory T.

AU - Arm, Christoph A.

AU - Leet, John E.

AU - Knight, John C.

AU - Pettit, Robin

AU - Chapuis, Jean

AU - Doubek, Dennis L.

AU - Ward, Franklin J.

AU - Weber, Christine

AU - Hooper, John N A

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AB - An investigation begun in 1979 directed at the Republic of Palau marine sponge Agelas axifera Hentschel for cancer cell growth inhibitory constituents subsequently led to the isolation of three new pyrimidine diterpenes designated axistatins 1 (1), 2 (2), and 3 (3), together with the previously reported formamides 4, 5, and agelasine F (6). The structures were elucidated by analysis of 2D-NMR spectra and by HRMS. All of the isolated compounds were found to be moderate inhibitors of cancer cell growth. Axistatins 1-3 (1-3), formamide 4, and agelasine F (6) also exhibited antimicrobial activity.

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Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel(1)

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