Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel(1)

George Pettit, Yuping Tang, Qingwen Zhang, Gregory T. Bourne, Christoph A. Arm, John E. Leet, John C. Knight, Robin Pettit, Jean Chapuis, Dennis L. Doubek, Franklin J. Ward, Christine Weber, John N A Hooper

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Abstract

An investigation begun in 1979 directed at the Republic of Palau marine sponge Agelas axifera Hentschel for cancer cell growth inhibitory constituents subsequently led to the isolation of three new pyrimidine diterpenes designated axistatins 1 (1), 2 (2), and 3 (3), together with the previously reported formamides 4, 5, and agelasine F (6). The structures were elucidated by analysis of 2D-NMR spectra and by HRMS. All of the isolated compounds were found to be moderate inhibitors of cancer cell growth. Axistatins 1-3 (1-3), formamide 4, and agelasine F (6) also exhibited antimicrobial activity.

Original languageEnglish (US)
Pages (from-to)420-424
Number of pages5
JournalJournal of Natural Products
Volume76
Issue number3
DOIs
StatePublished - Mar 22 2013

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ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Pettit, G., Tang, Y., Zhang, Q., Bourne, G. T., Arm, C. A., Leet, J. E., Knight, J. C., Pettit, R., Chapuis, J., Doubek, D. L., Ward, F. J., Weber, C., & Hooper, J. N. A. (2013). Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel(1). Journal of Natural Products, 76(3), 420-424. https://doi.org/10.1021/np300828y