Isolation and structure of the symmetrical disteroidal alkaloids cephalostatin 12 and cephalostatin 13

George Pettit, Yoshitatsu Ichihara, Jun-Ping Xu, Michael R. Boyd, Michael D. Williams

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Re-examination of a Western Indian Ocean worm Cephalodiscus gilchristi has led to discovery of cephalostatins 12 and 13. Cephalostatin 12 (2) proved to be the first example of a symmetrical disteroidal alkaloid. Both new cephalostatins significantly inhibited growth of animal and human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)1507-1512
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number12
DOIs
StatePublished - Jun 23 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Isolation and structure of the symmetrical disteroidal alkaloids cephalostatin 12 and cephalostatin 13'. Together they form a unique fingerprint.

Cite this