Isolation and structure of the symmetrical disteroidal alkaloids cephalostatin 12 and cephalostatin 13

George Pettit; Yoshitatsu Ichihara; Jun-Ping Xu; Michael R. Boyd; Michael D. Williams

doi:10.1016/S0960-894X(01)80522-9

Isolation and structure of the symmetrical disteroidal alkaloids cephalostatin 12 and cephalostatin 13

George Pettit, Yoshitatsu Ichihara, Jun-Ping Xu, Michael R. Boyd, Michael D. Williams

Research output: Contribution to journal › Article › peer-review

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Abstract

Re-examination of a Western Indian Ocean worm Cephalodiscus gilchristi has led to discovery of cephalostatins 12 and 13. Cephalostatin 12 (2) proved to be the first example of a symmetrical disteroidal alkaloid. Both new cephalostatins significantly inhibited growth of animal and human cancer cell lines.

Original language	English (US)
Pages (from-to)	1507-1512
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	12
DOIs	https://doi.org/10.1016/S0960-894X(01)80522-9
State	Published - Jun 23 1994

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)80522-9

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abstract = "Re-examination of a Western Indian Ocean worm Cephalodiscus gilchristi has led to discovery of cephalostatins 12 and 13. Cephalostatin 12 (2) proved to be the first example of a symmetrical disteroidal alkaloid. Both new cephalostatins significantly inhibited growth of animal and human cancer cell lines.",

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AU - Ichihara, Yoshitatsu

AU - Xu, Jun-Ping

AU - Boyd, Michael R.

AU - Williams, Michael D.

PY - 1994/6/23

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AB - Re-examination of a Western Indian Ocean worm Cephalodiscus gilchristi has led to discovery of cephalostatins 12 and 13. Cephalostatin 12 (2) proved to be the first example of a symmetrical disteroidal alkaloid. Both new cephalostatins significantly inhibited growth of animal and human cancer cell lines.

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Isolation and structure of the symmetrical disteroidal alkaloids cephalostatin 12 and cephalostatin 13

Abstract

ASJC Scopus subject areas

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