Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

George Pettit, S. B. Singh, E. Hamel, C. M. Lin, D. S. Alberts, D. Garcia-Kendal

Research output: Contribution to journalArticlepeer-review

677 Scopus citations

Abstract

The African tree Combretum caffrum (Combretaceae) has been found to contain a powerful inhibitor of tubulin polymerization (IC502-3 μM), the growth of murine lymphocytic leukemia (L 1210 and P 388 with ED50≈0.003 μM and human colon cancer cell lines [(e.g. LoVo (ED50=0.005 μg/ml), HT29 (ED50 0.02 μg/ml, Colo 205 (ED50=0.07 μg/ml), DLD-1 (ED50=0.005 μg/ml) and HCT-15 (ED50=0.0009 μg/ml)] designated combretastatin A-4 (1c). The structure assigned by spectral techniques was confirmed by synthesis.

Original languageEnglish (US)
Pages (from-to)209-211
Number of pages3
JournalExperientia
Volume45
Issue number2
DOIs
StatePublished - Feb 1 1989

Keywords

  • Combretum caffrum
  • combretaceae
  • combretastatin A-4
  • human colon cancer
  • inhibitor tubulin
  • lymphocytic leukemia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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