Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera (porifera)

George Pettit, Cherry L. Herald, Zbigniew Cichacz, Feng Gao, Jean M. Schmidt, Michael R. Boyd, Nigel D. Christie, Fred E. Boettner

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

The Southwest Indian Ocean marine sponge Spirastrella spinispirulifera has been found to contain (in 10-7% yields) two extraordinarily potent (Gl50 ca. 10-8 μg ml-1) human cancer cell line inhibitors designated spongistatins 4 1d and 5 2.

Original languageEnglish (US)
Pages (from-to)1805-1807
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number24
DOIs
Publication statusPublished - 1993

    Fingerprint

ASJC Scopus subject areas

  • Molecular Medicine

Cite this