Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera (porifera)

George Pettit, Cherry L. Herald, Zbigniew Cichacz, Feng Gao, Jean M. Schmidt, Michael R. Boyd, Nigel D. Christie, Fred E. Boettner

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The Southwest Indian Ocean marine sponge Spirastrella spinispirulifera has been found to contain (in 10-7% yields) two extraordinarily potent (Gl50 ca. 10-8 μg ml-1) human cancer cell line inhibitors designated spongistatins 4 1d and 5 2.

Original languageEnglish (US)
Pages (from-to)1805-1807
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number24
DOIs
StatePublished - 1993

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Indian Ocean
Growth Inhibitors
Porifera
Cells
Cell Line
Neoplasms

ASJC Scopus subject areas

  • Molecular Medicine

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Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera (porifera). / Pettit, George; Herald, Cherry L.; Cichacz, Zbigniew; Gao, Feng; Schmidt, Jean M.; Boyd, Michael R.; Christie, Nigel D.; Boettner, Fred E.

In: Journal of the Chemical Society, Chemical Communications, No. 24, 1993, p. 1805-1807.

Research output: Contribution to journalArticle

Pettit, George ; Herald, Cherry L. ; Cichacz, Zbigniew ; Gao, Feng ; Schmidt, Jean M. ; Boyd, Michael R. ; Christie, Nigel D. ; Boettner, Fred E. / Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera (porifera). In: Journal of the Chemical Society, Chemical Communications. 1993 ; No. 24. pp. 1805-1807.
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