Isolation and structure of the human cancer cell growth inhibitory phakellistatin 4 from the western Pacific sponge Phakellia costata

George Pettit; Jun-Ping Xu; Zbigniew Cichacz; Jean M. Schmidt; Ann Christine Dorsaz; Michael R. Boyd; Ronald L. Cerny

doi:10.3987/com-94-s45

Isolation and structure of the human cancer cell growth inhibitory phakellistatin 4 from the western Pacific sponge Phakellia costata

George Pettit, Jun-Ping Xu, Zbigniew Cichacz, Jean M. Schmidt, Ann Christine Dorsaz, Michael R. Boyd, Ronald L. Cerny

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Structural elucidation by high field 2D nmr and FAB-ms/ms techniques led to cyclo-(Pro-Thr-Pro-Phe-Ile-Phe-Ser) as the assignment for phakellistatin(4) a new cell growth inhibitory peptide from the Chuuk Archipelago marine sponge Phakellia costata.

Original language	English (US)
Pages (from-to)	501-506
Number of pages	6
Journal	Heterocycles
Volume	40
Issue number	2
DOIs	https://doi.org/10.3987/com-94-s45
State	Published - Mar 1 1995

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Isolation and structure of the human cancer cell growth inhibitory phakellistatin 4 from the western Pacific sponge Phakellia costata",

abstract = "Structural elucidation by high field 2D nmr and FAB-ms/ms techniques led to cyclo-(Pro-Thr-Pro-Phe-Ile-Phe-Ser) as the assignment for phakellistatin(4) a new cell growth inhibitory peptide from the Chuuk Archipelago marine sponge Phakellia costata.",

author = "George Pettit and Jun-Ping Xu and Zbigniew Cichacz and Schmidt, {Jean M.} and Dorsaz, {Ann Christine} and Boyd, {Michael R.} and Cerny, {Ronald L.}",

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AU - Pettit, George

AU - Xu, Jun-Ping

AU - Cichacz, Zbigniew

AU - Schmidt, Jean M.

AU - Dorsaz, Ann Christine

AU - Boyd, Michael R.

AU - Cerny, Ronald L.

PY - 1995/3/1

Y1 - 1995/3/1

N2 - Structural elucidation by high field 2D nmr and FAB-ms/ms techniques led to cyclo-(Pro-Thr-Pro-Phe-Ile-Phe-Ser) as the assignment for phakellistatin(4) a new cell growth inhibitory peptide from the Chuuk Archipelago marine sponge Phakellia costata.

AB - Structural elucidation by high field 2D nmr and FAB-ms/ms techniques led to cyclo-(Pro-Thr-Pro-Phe-Ile-Phe-Ser) as the assignment for phakellistatin(4) a new cell growth inhibitory peptide from the Chuuk Archipelago marine sponge Phakellia costata.

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Isolation and structure of the human cancer cell growth inhibitory phakellistatin 4 from the western Pacific sponge Phakellia costata

Abstract

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