Isolation and structure of the human cancer cell growth inhibitory phakellistatin 4 from the western Pacific sponge Phakellia costata

George Pettit, Jun-Ping Xu, Zbigniew Cichacz, Jean M. Schmidt, Ann Christine Dorsaz, Michael R. Boyd, Ronald L. Cerny

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Structural elucidation by high field 2D nmr and FAB-ms/ms techniques led to cyclo-(Pro-Thr-Pro-Phe-Ile-Phe-Ser) as the assignment for phakellistatin(4) a new cell growth inhibitory peptide from the Chuuk Archipelago marine sponge Phakellia costata.

Original languageEnglish (US)
Pages (from-to)501-506
Number of pages6
JournalHeterocycles
Volume40
Issue number2
DOIs
StatePublished - Mar 1 1995

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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