Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16

George Pettit, Jun-Ping Xu, Fiona Hogan, Michael D. Williams, Dennis L. Doubek, Jean M. Schmidt, Ronald L. Cerny, Michael R. Boyd

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

An investigation of the sea hare Dolabella auricularia from Papua New Guinea has led to discovery of the new cyclodepsipeptide dolastatin 16 (3) containing two new amino acid units designated dolamethylleuine (Dml) and dolaphenvaline (Dpv). The structural elucidation was achieved by means of high-field (500 MHz) NMR and tandem MS/MS mass spectral interpretations and allowed the assignment cyclo-(Pro-Dpv-Pro-Dml-O-Lac-Pro-O-Hiv-MeVal). The new depsipeptide exhibited strong inhibition of growth against a variety of human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)752-754
Number of pages3
JournalJournal of Natural Products
Volume60
Issue number8
DOIs
StatePublished - Aug 1997

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Pettit, G., Xu, J-P., Hogan, F., Williams, M. D., Doubek, D. L., Schmidt, J. M., Cerny, R. L., & Boyd, M. R. (1997). Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16. Journal of Natural Products, 60(8), 752-754. https://doi.org/10.1021/np9700230