Isolation and structure of the human cancer cell growth inhibitory cyclic decapeptides phakellistatins 7, 8 and 91,2

George Pettit, Jun-Ping Xu, Ann Christine Dorsaz, Michael D. Williams, Michael R. Boyd, Ronald L. Cerny

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Phakellistatins 7-9 respresent the first cancer cell growth inhibitory (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides. Each was isolated from the Federated States of Micronesia (Chuuk) marine sponge Phakellia costata. The Federated States of Micronesia (Chuuk) marine sponge Phakellia costata has been found to contain (10-5 and 10-6% yields) three cancer cell line active (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides named phakellistatins 7 (1), 8 (2) and 9 (3). Phakellistatins 7-9 represent the first cancer cell growth inhibitory cyclic decapeptides isolated from a marine sponge.

Original languageEnglish (US)
Pages (from-to)1339-1344
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number13
DOIs
StatePublished - Jul 6 1995

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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