Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15

George Pettit; Yoshiaki Kamano; Claude Dufresne; Ronald L. Cerny; Cherry L. Herald; Jean M. Schmidt

doi:10.1021/jo00287a003

Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15

George Pettit, Yoshiaki Kamano, Claude Dufresne, Ronald L. Cerny, Cherry L. Herald, Jean M. Schmidt

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Abstract

The Indian Ocean sea hare Dolabella auricularia has been found to contain a strongly cytostatic depsipeptide constituent designated dolastatin 15. The unusual depsipeptide was found to markedly inhibit growth of the P388 lymphocytic leukemia cell line with ED₅₀= 0.0024 μg/mL. The structure was elucidated by employing primarily high-field (400-MHz) 2D NMR and high-resolution mass spectrometry.

Original language	English (US)
Pages (from-to)	6005-6006
Number of pages	2
Journal	Journal of Organic Chemistry
Volume	54
Issue number	26
DOIs	https://doi.org/10.1021/jo00287a003
State	Published - Dec 1 1989

ASJC Scopus subject areas

Organic Chemistry

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title = "Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15",

abstract = "The Indian Ocean sea hare Dolabella auricularia has been found to contain a strongly cytostatic depsipeptide constituent designated dolastatin 15. The unusual depsipeptide was found to markedly inhibit growth of the P388 lymphocytic leukemia cell line with ED50= 0.0024 μg/mL. The structure was elucidated by employing primarily high-field (400-MHz) 2D NMR and high-resolution mass spectrometry.",

author = "George Pettit and Yoshiaki Kamano and Claude Dufresne and Cerny, {Ronald L.} and Herald, {Cherry L.} and Schmidt, {Jean M.}",

year = "1989",

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journal = "Journal of Organic Chemistry",

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T1 - Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15

AU - Pettit, George

AU - Kamano, Yoshiaki

AU - Dufresne, Claude

AU - Cerny, Ronald L.

AU - Herald, Cherry L.

AU - Schmidt, Jean M.

PY - 1989/12/1

Y1 - 1989/12/1

N2 - The Indian Ocean sea hare Dolabella auricularia has been found to contain a strongly cytostatic depsipeptide constituent designated dolastatin 15. The unusual depsipeptide was found to markedly inhibit growth of the P388 lymphocytic leukemia cell line with ED50= 0.0024 μg/mL. The structure was elucidated by employing primarily high-field (400-MHz) 2D NMR and high-resolution mass spectrometry.

AB - The Indian Ocean sea hare Dolabella auricularia has been found to contain a strongly cytostatic depsipeptide constituent designated dolastatin 15. The unusual depsipeptide was found to markedly inhibit growth of the P388 lymphocytic leukemia cell line with ED50= 0.0024 μg/mL. The structure was elucidated by employing primarily high-field (400-MHz) 2D NMR and high-resolution mass spectrometry.

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U2 - 10.1021/jo00287a003

DO - 10.1021/jo00287a003

M3 - Article

AN - SCOPUS:0024850791

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 26

ER -

Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15

Abstract

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