Isolation and structure of the cytostatic linear depsipeptide dolastatin 15

George Pettit, Yoshiaki Kamano, Claude Dufresne, Ronald L. Cerny, Cherry L. Herald, Jean M. Schmidt

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

The Indian Ocean sea hare Dolabella auricularia has been found to contain a strongly cytostatic depsipeptide constituent designated dolastatin 15. The unusual depsipeptide was found to markedly inhibit growth of the P388 lymphocytic leukemia cell line with ED50 = 0.0024 μg/mL. The structure was elucidated by employing primarily high-field (400-MHz) 2D NMR and high-resolution mass spectrometry.

Original languageEnglish (US)
Pages (from-to)6005-6006
Number of pages2
JournalJournal of Organic Chemistry
Volume54
Issue number26
StatePublished - 1989

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Depsipeptides
Cytostatic Agents
Mass spectrometry
Cells
Nuclear magnetic resonance
dolastatin 15

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Pettit, G., Kamano, Y., Dufresne, C., Cerny, R. L., Herald, C. L., & Schmidt, J. M. (1989). Isolation and structure of the cytostatic linear depsipeptide dolastatin 15. Journal of Organic Chemistry, 54(26), 6005-6006.

Isolation and structure of the cytostatic linear depsipeptide dolastatin 15. / Pettit, George; Kamano, Yoshiaki; Dufresne, Claude; Cerny, Ronald L.; Herald, Cherry L.; Schmidt, Jean M.

In: Journal of Organic Chemistry, Vol. 54, No. 26, 1989, p. 6005-6006.

Research output: Contribution to journalArticle

Pettit, G, Kamano, Y, Dufresne, C, Cerny, RL, Herald, CL & Schmidt, JM 1989, 'Isolation and structure of the cytostatic linear depsipeptide dolastatin 15', Journal of Organic Chemistry, vol. 54, no. 26, pp. 6005-6006.
Pettit G, Kamano Y, Dufresne C, Cerny RL, Herald CL, Schmidt JM. Isolation and structure of the cytostatic linear depsipeptide dolastatin 15. Journal of Organic Chemistry. 1989;54(26):6005-6006.
Pettit, George ; Kamano, Yoshiaki ; Dufresne, Claude ; Cerny, Ronald L. ; Herald, Cherry L. ; Schmidt, Jean M. / Isolation and structure of the cytostatic linear depsipeptide dolastatin 15. In: Journal of Organic Chemistry. 1989 ; Vol. 54, No. 26. pp. 6005-6006.
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