Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A

George Pettit, Daniel E. Schaufelberger

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

An unusual cytostatic (PS ED50 4 μg/ml) lignan ester has been isolated from the Central American tree Phyllanthus acuminatus and designated phyllanthostatin A [1]. Separation of an MeOH extract of the root by size exclusion chromatography, high speed counter-current distribution, and semipreparative hplc afforded glycoside 1 in 0.007% yield. In solution, phyllanthostatin A was slowly transformed into justicidin B [4], The structure of lignan glycoside 1 was determined by hrfabms and 2D-nmr spectroscopy.

Original languageEnglish (US)
Pages (from-to)1104-1112
Number of pages9
JournalJournal of Natural Products
Volume51
Issue number6
StatePublished - 1988

Fingerprint

Lignans
Cytostatic Agents
lignans
Glycosides
glycosides
Phyllanthus
Size exclusion chromatography
Gel Chromatography
spectroscopy
Spectrum Analysis
Esters
esters
Spectroscopy
extracts
phyllanthostatin A
justicidin A
gel chromatography

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A. / Pettit, George; Schaufelberger, Daniel E.

In: Journal of Natural Products, Vol. 51, No. 6, 1988, p. 1104-1112.

Research output: Contribution to journalArticle

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