Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A

George Pettit, Daniel E. Schaufelberger

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

An unusual cytostatic (PS ED504 μg/ml) lignan ester has been isolated from the Central American tree Phyllanthus acuminatus and designated phyllanthostatin A {1}. Separation of an MeOH extract of the root by size exclusion chromatography, high speed counter-current distribution, and semipreparative hplc afforded glycoside 1 in 0.007% yield. In solution, phyllanthostatin A was slowly transformed into justicidin B [4]. The structure of lignan glycoside 1 was determined by hrfabms and 2D-nmr spectroscopy.

Original languageEnglish (US)
Pages (from-to)1104-1112
Number of pages9
JournalJournal of Natural Products
Volume51
Issue number6
DOIs
StatePublished - Nov 1988

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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