Abstract
Two antineoplastic cyclic depsipeptides designated dolastatin 11(1) and dolastatin 12 (2) were isolated from the Indian Ocean sea hare Dolabella auricularia. Dolastatins 11 and 12 inhibited growth of the PS leukemia with ED50 2.7 × 10-3 and 7.5 × 10-2 μg/mL respectively. Detailed structural studies employing 400 MHz 1H,1H-COSY, 1H,13C-COSY, NOE, and HMBC experiments (in addition to acid and base hydrolysis, followed by GC-MS analysis) led to structure 1 for dolastatin 11 and to structure 2 for dolastatin 12.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 553-558 |
| Number of pages | 6 |
| Journal | Heterocycles |
| Volume | 28 |
| Issue number | 2 |
| State | Published - Jan 1 1989 |
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ASJC Scopus subject areas
- Organic Chemistry
Cite this
Isolation and structure of the cell growth inhibitory depsipeptides dolastatins 11 and 12. / Pettit, George; Kamano, Yoshiaki; Kizu, Haruhisa; Dufresne, Claude; Herald, Cherry L.; Bontems, Roger J.; Schmidt, Jean M.; Boettner, Fred E.; Nieman, Ronald A.
In: Heterocycles, Vol. 28, No. 2, 01.01.1989, p. 553-558.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isolation and structure of the cell growth inhibitory depsipeptides dolastatins 11 and 12
AU - Pettit, George
AU - Kamano, Yoshiaki
AU - Kizu, Haruhisa
AU - Dufresne, Claude
AU - Herald, Cherry L.
AU - Bontems, Roger J.
AU - Schmidt, Jean M.
AU - Boettner, Fred E.
AU - Nieman, Ronald A.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - Two antineoplastic cyclic depsipeptides designated dolastatin 11(1) and dolastatin 12 (2) were isolated from the Indian Ocean sea hare Dolabella auricularia. Dolastatins 11 and 12 inhibited growth of the PS leukemia with ED50 2.7 × 10-3 and 7.5 × 10-2 μg/mL respectively. Detailed structural studies employing 400 MHz 1H,1H-COSY, 1H,13C-COSY, NOE, and HMBC experiments (in addition to acid and base hydrolysis, followed by GC-MS analysis) led to structure 1 for dolastatin 11 and to structure 2 for dolastatin 12.
AB - Two antineoplastic cyclic depsipeptides designated dolastatin 11(1) and dolastatin 12 (2) were isolated from the Indian Ocean sea hare Dolabella auricularia. Dolastatins 11 and 12 inhibited growth of the PS leukemia with ED50 2.7 × 10-3 and 7.5 × 10-2 μg/mL respectively. Detailed structural studies employing 400 MHz 1H,1H-COSY, 1H,13C-COSY, NOE, and HMBC experiments (in addition to acid and base hydrolysis, followed by GC-MS analysis) led to structure 1 for dolastatin 11 and to structure 2 for dolastatin 12.
UR - http://www.scopus.com/inward/record.url?scp=0000067997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0000067997&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0000067997
VL - 28
SP - 553
EP - 558
JO - Heterocycles
JF - Heterocycles
SN - 0385-5414
IS - 2
ER -