Two antineoplastic cyclic depsipeptides designated dolastatin 11(1) and dolastatin 12 (2) were isolated from the Indian Ocean sea hare Dolabella auricularia. Dolastatins 11 and 12 inhibited growth of the PS leukemia with ED50 2.7 × 10-3 and 7.5 × 10-2 μg/mL respectively. Detailed structural studies employing 400 MHz 1H,1H-COSY, 1H,13C-COSY, NOE, and HMBC experiments (in addition to acid and base hydrolysis, followed by GC-MS analysis) led to structure 1 for dolastatin 11 and to structure 2 for dolastatin 12.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Jan 1 1989|
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry