Isolation and structure of the cancer cell growth inhibitor dictyostatin 1

George Pettit; Zbigniew Cichacz; Feng Gao; Michael R. Boyd; Jean M. Schmidt

doi:10.1039/C39940001111

Isolation and structure of the cancer cell growth inhibitor dictyostatin 1

George Pettit, Zbigniew Cichacz, Feng Gao, Michael R. Boyd, Jean M. Schmidt

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136 Scopus citations

Abstract

Dictyostatin 1 2, a new type of macrocyclic lactone bearing a 22-membered ring system, has been isolated (3.4 × 10^-7% yield) from a Republic of Maldives marine sponge in the genus Spongia and found to strongly inhibit growth of the murine P388 lymphocytic leukaemia.

Original language	English (US)
Pages (from-to)	1111-1112
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	9
DOIs	https://doi.org/10.1039/C39940001111
State	Published - 1994

ASJC Scopus subject areas

Molecular Medicine

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title = "Isolation and structure of the cancer cell growth inhibitor dictyostatin 1",

abstract = "Dictyostatin 1 2, a new type of macrocyclic lactone bearing a 22-membered ring system, has been isolated (3.4 × 10-7% yield) from a Republic of Maldives marine sponge in the genus Spongia and found to strongly inhibit growth of the murine P388 lymphocytic leukaemia.",

author = "George Pettit and Zbigniew Cichacz and Feng Gao and Boyd, {Michael R.} and Schmidt, {Jean M.}",

year = "1994",

doi = "10.1039/C39940001111",

language = "English (US)",

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journal = "Journal of the Chemical Society D: Chemical Communications",

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T1 - Isolation and structure of the cancer cell growth inhibitor dictyostatin 1

AU - Pettit, George

AU - Cichacz, Zbigniew

AU - Gao, Feng

AU - Boyd, Michael R.

AU - Schmidt, Jean M.

PY - 1994

Y1 - 1994

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AB - Dictyostatin 1 2, a new type of macrocyclic lactone bearing a 22-membered ring system, has been isolated (3.4 × 10-7% yield) from a Republic of Maldives marine sponge in the genus Spongia and found to strongly inhibit growth of the murine P388 lymphocytic leukaemia.

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DO - 10.1039/C39940001111

M3 - Article

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JO - Journal of the Chemical Society D: Chemical Communications

JF - Journal of the Chemical Society D: Chemical Communications

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Isolation and structure of the cancer cell growth inhibitor dictyostatin 1

Abstract

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