Isolation and structure of the cancer cell growth inhibitor dictyostatin 1

George Pettit, Zbigniew Cichacz, Feng Gao, Michael R. Boyd, Jean M. Schmidt

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Dictyostatin 1 2, a new type of macrocyclic lactone bearing a 22-membered ring system, has been isolated (3.4 × 10-7% yield) from a Republic of Maldives marine sponge in the genus Spongia and found to strongly inhibit growth of the murine P388 lymphocytic leukaemia.

Original languageEnglish (US)
Pages (from-to)1111-1112
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number9
DOIs
StatePublished - 1994

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Bearings (structural)
Indian Ocean Islands
Lymphoid Leukemia
Growth Inhibitors
Porifera
Lactones
Growth
Neoplasms
dictyostatin

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Isolation and structure of the cancer cell growth inhibitor dictyostatin 1. / Pettit, George; Cichacz, Zbigniew; Gao, Feng; Boyd, Michael R.; Schmidt, Jean M.

In: Journal of the Chemical Society, Chemical Communications, No. 9, 1994, p. 1111-1112.

Research output: Contribution to journalArticle

Pettit, George ; Cichacz, Zbigniew ; Gao, Feng ; Boyd, Michael R. ; Schmidt, Jean M. / Isolation and structure of the cancer cell growth inhibitor dictyostatin 1. In: Journal of the Chemical Society, Chemical Communications. 1994 ; No. 9. pp. 1111-1112.
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