Isolation and structure of the cancer cell growth inhibitor dictyostatin 1

George Pettit, Zbigniew Cichacz, Feng Gao, Michael R. Boyd, Jean M. Schmidt

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

Dictyostatin 1 2, a new type of macrocyclic lactone bearing a 22-membered ring system, has been isolated (3.4 × 10-7% yield) from a Republic of Maldives marine sponge in the genus Spongia and found to strongly inhibit growth of the murine P388 lymphocytic leukaemia.

Original languageEnglish (US)
Pages (from-to)1111-1112
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number9
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Molecular Medicine

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