Abstract
A new cell growth inhibitory (P388 lymphocytic leukemia ED50 0.8 μg/mL) cycloheptapeptide designated stylostatin 1 (1) has been isolated from the south Pacific Ocean sponge Stylotella aurantium Kelly-Borges and Bergquist. Structural determination was accomplished primarily by utilizing high-field 1H-NMR (500 MHz) with appropriate 2D-NMR experiments and was confirmed by X-ray crystallographic analysis. The absolute configuration (established by chiral gas chromatographic analysis) and crystal structure conformation (with hydrogen bonding) for stylostatin 1 (1) were determined.
Original language | English (US) |
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Pages (from-to) | 7217-7220 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 57 |
Issue number | 26 |
DOIs | |
State | Published - Dec 1 1992 |
ASJC Scopus subject areas
- Organic Chemistry