Isolation and Structure of Stylostatin 1 from the Papua New Guinea Marine Sponge Stylotella aurantium

George Pettit, Jayaram K. Srirangam, Delbert L. Herald, Karen L. Erickson, Dennis L. Doubek, Jean M. Schmidt, Larry P. Tackett, Gerald J. Bakus

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

A new cell growth inhibitory (P388 lymphocytic leukemia ED50 0.8 μg/mL) cycloheptapeptide designated stylostatin 1 (1) has been isolated from the south Pacific Ocean sponge Stylotella aurantium Kelly-Borges and Bergquist. Structural determination was accomplished primarily by utilizing high-field 1H-NMR (500 MHz) with appropriate 2D-NMR experiments and was confirmed by X-ray crystallographic analysis. The absolute configuration (established by chiral gas chromatographic analysis) and crystal structure conformation (with hydrogen bonding) for stylostatin 1 (1) were determined.

Original languageEnglish (US)
Pages (from-to)7217-7220
Number of pages4
JournalJournal of Organic Chemistry
Volume57
Issue number26
DOIs
StatePublished - Dec 1 1992

ASJC Scopus subject areas

  • Organic Chemistry

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