Isolation and Structure of Spongistatin 1

George Pettit, Zbigniew Cichacz, Feng Gao, Cherry L. Herald, Michael R. Boyd, Jean M. Schmidt, John N A Hooper

Research output: Contribution to journalArticle

298 Scopus citations


An Eastern Indian Ocean sponge in the genus Spongia contains a structurally unprecedented macrocyclic lactone, spongistatin 1 (3), with extremely potent activity against selected human tumor cell types in the U.S. National Cancer Institute's primary screen.

Original languageEnglish (US)
Pages (from-to)1302-1304
Number of pages3
JournalJournal of Organic Chemistry
Issue number6
StatePublished - Jan 1 1993


ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Pettit, G., Cichacz, Z., Gao, F., Herald, C. L., Boyd, M. R., Schmidt, J. M., & Hooper, J. N. A. (1993). Isolation and Structure of Spongistatin 1. Journal of Organic Chemistry, 58(6), 1302-1304.