Isolation and structure of spongilipid from the Republic of Singapore marine porifera Spongia cf. hispida

George Pettit, Timothy J. Bond, Delbert L. Herald, Martin Penny, Dennis L. Doubek, Michael D. Williams, Robin Pettit, John N A Hooper

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Cell growth inhibitory (P388 lymphocytic leukemia) fractions from the purple marine sponge Spongia cf. hispida were employed to uncover a new biologically active monogalactosyl monoglyceride designated spongilipid (5a). The structure and absolute configuration of spongilipid was established by X-ray crystallography. Spongilipid specifically inhibited growth of the fecal opportunist Enterococcus faecalis.

Original languageEnglish (US)
Pages (from-to)920-925
Number of pages6
JournalCanadian Journal of Chemistry
Volume75
Issue number6
DOIs
StatePublished - Jan 1 1997

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Keywords

  • Marine sponge
  • Spongia hispida
  • Spongilipid

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

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