Isolation and structure of phakellistatin 14 from the western pacific marine sponge Phakellia sp.

George Pettit, Rui Tan

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

A new cycloheptapeptide, phakellistatin 14, was isolated in 8.8 × 10-7% yield from Phakellia sp., a marine sponge from Chuuk, Federated States of Micronesia. The structure (1), cyclo-Phe-β-OMe-Asp-Ala-Met-(SO)- Ala-Ile-Pro, was elucidated by 1D and 2D NMR spectral analyses augmented by HRFABMS. The chirality of each amino acid unit was determined to be S using chiral HPLC methods. Phakellistatin 14 showed cancer cell growth inhibitory activity (ED50 5 μg/mL) against the murine lymphocytic leukemia P388 cell line.

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalJournal of Natural Products
Volume68
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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