Isolation and structure of pedilstatin from a Republic of Maldives Pedilanthus sp.

George Pettit, Sylvie Ducki, Rui Tan, Roberta S. Gardella, James B. McMahon, Michael R. Boyd, George R. Pettit, Peter M. Blumberg, Nancy E. Lewin, Dennis L. Doubek, Larry P. Tackett, Michael D. Williams

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A new cancer cell growth inhibitor designated pedilstatin (1) was isolated from a Republic of Maldives Pedilanthus sp. The structure was determined to be 13-Oacetyl-12-O-[2′Z,4′-octadienoyl]-4α-deoxyphorbol on the basis of high-resolution mass spectral and 2D NMR assignments. Pedilstatin was found to significantly inhibit growth of the P388 lymphocytic leukemia cell line with an ED50 of 0.28 μg/mL, to afford, at concentrations of 2-5 μM, protection (to 80%) of human-derived lymphoblastoid CEM-SS cells from infection and cell-killing by HIV-1, and to show inhibition of protein kinase C with a Ki of 620 ± 20 nM.

Original languageEnglish (US)
Pages (from-to)1262-1265
Number of pages4
JournalJournal of Natural Products
Volume65
Issue number9
DOIs
StatePublished - Sep 1 2002

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Pettit, G., Ducki, S., Tan, R., Gardella, R. S., McMahon, J. B., Boyd, M. R., Pettit, G. R., Blumberg, P. M., Lewin, N. E., Doubek, D. L., Tackett, L. P., & Williams, M. D. (2002). Isolation and structure of pedilstatin from a Republic of Maldives Pedilanthus sp. Journal of Natural Products, 65(9), 1262-1265. https://doi.org/10.1021/np020115b