Isolation and structure of palstatin from the amazon tree Hymeneae palustris

George Pettit, Yanhui Meng, Clare A. Stevenson, Dennis L. Doubek, John C. Knight, Zbigniew Cichacz, Robin Pettit, Jean Chapuis, Jean M. Schmidt

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Bioassay (P388 lymphocytic leukemia cell line and human cancer cell lines) guided separation of an extract prepared from the leaves of Hymenaea palustris Ducké led to the isolation of six cancer cell growth inhibitory flavonoids (1-6). The structures were elucidated by HRMS and 1D and 2D NMR spectral analysis. The new flavonolignan 1 designated palstatin proved to be a methoxy structural modification of 5′-methoxyhydnocarpin-D (2). Flavones 1-4 inhibited growth of the pathogenic bacteria Enterococcus faecalis and/or Neisseria gonorrhoeae.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalJournal of Natural Products
Volume66
Issue number2
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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