Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta

George Pettit, Mark S. Butler, Michael D. Williams, Melanie J. Filiatrault, Robin Pettit

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Further investigation of the Bismarck Archipelago (Papua New Guinea) marine sponge Ianthella basta for biologically active constituents has led to the isolation of hemibastadins 1 (2), 2 (3), and 3 (4) and the new brominated tyrosine derivatives hemibastadinols 1-3 (9, 13, and 14). Isolation and structure elucidation of the monomethyl ether derivatives (7 and 8) of hemibastadins 1 and 2 and the 3-bromotyramine amide of oxalic acid amide (1a) concluded our chemical investigation of I. basta. The hemibastadins and hemibastadinols represent important biosynthetic links to a series of bromotyrosine tetramers collectively known as the bastadins. The antimicrobial activity of the bastadins, hemibastadins, and hemibastadinols is summarized.

Original languageEnglish (US)
Pages (from-to)927-934
Number of pages8
JournalJournal of Natural Products
Volume59
Issue number10
DOIs
StatePublished - Oct 1996

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta'. Together they form a unique fingerprint.

Cite this