Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala

George Pettit, Qingwen Zhang, Véronique Pinilla, Delbert L. Herald, Dennis L. Doubek, James A. Duke

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A bioassay-guided investigation of Gustavia hexapetala led to the isolation of a new cancer cell growth inhibitor designated gustastatin (1) and four previously known cancer cell growth inhibitors that included betulinic acid (2). The structures were assigned on the basis of analyses of HRMS combined with 1D and 2D NMR data. The structure of portentol (5) was confirmed by an X-ray crystal structure determination.

Original languageEnglish (US)
Pages (from-to)983-985
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number6
DOIs
StatePublished - Jun 2004

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala'. Together they form a unique fingerprint.

Cite this