Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala

George Pettit; Qingwen Zhang; Véronique Pinilla; Delbert L. Herald; Dennis L. Doubek; James A. Duke

doi:10.1021/np030509i

Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala

George Pettit, Qingwen Zhang, Véronique Pinilla, Delbert L. Herald, Dennis L. Doubek, James A. Duke

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A bioassay-guided investigation of Gustavia hexapetala led to the isolation of a new cancer cell growth inhibitor designated gustastatin (1) and four previously known cancer cell growth inhibitors that included betulinic acid (2). The structures were assigned on the basis of analyses of HRMS combined with 1D and 2D NMR data. The structure of portentol (5) was confirmed by an X-ray crystal structure determination.

Original language	English (US)
Pages (from-to)	983-985
Number of pages	3
Journal	Journal of Natural Products
Volume	67
Issue number	6
DOIs	https://doi.org/10.1021/np030509i
State	Published - Jun 2004

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np030509i

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abstract = "A bioassay-guided investigation of Gustavia hexapetala led to the isolation of a new cancer cell growth inhibitor designated gustastatin (1) and four previously known cancer cell growth inhibitors that included betulinic acid (2). The structures were assigned on the basis of analyses of HRMS combined with 1D and 2D NMR data. The structure of portentol (5) was confirmed by an X-ray crystal structure determination.",

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AU - Pinilla, Véronique

AU - Herald, Delbert L.

AU - Doubek, Dennis L.

AU - Duke, James A.

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Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala

Abstract

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