Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala

George Pettit, Qingwen Zhang, Véronique Pinilla, Delbert L. Herald, Dennis L. Doubek, James A. Duke

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A bioassay-guided investigation of Gustavia hexapetala led to the isolation of a new cancer cell growth inhibitor designated gustastatin (1) and four previously known cancer cell growth inhibitors that included betulinic acid (2). The structures were assigned on the basis of analyses of HRMS combined with 1D and 2D NMR data. The structure of portentol (5) was confirmed by an X-ray crystal structure determination.

Original languageEnglish (US)
Pages (from-to)983-985
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number6
DOIs
StatePublished - Jun 1 2004

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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