Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su

T. Nogawa, Y. Kamano, A. Yamashita, George Pettit

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

Five new bufadienolides, 3β-formyloxyresibufogenin (1), 19-oxobufalin (2), 19-oxodesacetylcinobufagin (3), 6α-hydroxycinobufagin (4), and 1β-hydroxybufalin (5), have been isolated together with the previously known bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the KB and HL-60 cancer cell lines. In addition, bufadienolide 1 was found active against the MH-60 cancer cell line.

Original languageEnglish (US)
Pages (from-to)1148-1152
Number of pages5
JournalJournal of Natural Products
Volume64
Issue number9
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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