Abstract
Five new bufadienolides, 3β-formyloxyresibufogenin (1), 19-oxobufalin (2), 19-oxodesacetylcinobufagin (3), 6α-hydroxycinobufagin (4), and 1β-hydroxybufalin (5), have been isolated together with the previously known bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the KB and HL-60 cancer cell lines. In addition, bufadienolide 1 was found active against the MH-60 cancer cell line.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1148-1152 |
| Number of pages | 5 |
| Journal | Journal of Natural Products |
| Volume | 64 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2001 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry