Isolation and structure of cytostatic steroidal saponins from the african medicinal plant balanites aegyptica

George Pettit, Dennis L. Doubek, Delbert L. Herald, Atsushi Numata, Chika Takahasi, Ryoko Fujiki, Tamie Miyamoto

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Bioactivity-guided separation of a CH2Cl2/MeOH extract of Balanites aegyptica afforded four new cytostatic saponins, named balanitins 4 [1], 5 [2], 6 [3], and 7 [4]. On the basis of enzymatic hydrolyses and glycosidation nmr chemical shifts employing the peracetates, structures 1–4 were established as yamogenin 3β-0-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2) -β-d- glucopyranoside [1], yamogenin 3β-0-α-l-rhamnopyranosyl-(1→3)-β-D-glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)] -β-d-glucopyranoside [2], yamogenin 3β-0-β-D-glucopyranosyl-(1→4)-[α-L-rham-nopyranosyl-(1→2)] -β-d--glucopyranoside [3], and diosgenin 3β-0-β-D-xylopyranosyl-(1→3)-β-d-glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)] -β-d-gIucopyranoside [4].

Original languageEnglish (US)
Pages (from-to)1491-1502
Number of pages12
JournalJournal of Natural Products
Volume54
Issue number6
DOIs
StatePublished - Nov 1 1991

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Isolation and structure of cytostatic steroidal saponins from the african medicinal plant balanites aegyptica'. Together they form a unique fingerprint.

Cite this