Isolation and structure of cephalostatins 10 and 11

George Pettit, Jun-Ping Xu, Michael D. Williams, Nigel D. Christie, Dennis L. Doubek, Jean M. Schmidt, Michael R. Boyd

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Further investigation of antineoplastic constituents from the marine worm Cephalodiscus gilchristi, employing a 450 kg re-collection from the Indian Ocean (Southeast Africa), has led to isolation and structural determination of two previously undetected members of the cephalostatin series, designated cephalostatins 10 [4] and 11 [5]. Structural analyses were conducted primarily employing high field 2D nmr and high resolution mass spectral techniques. All the stereochemical assignments were deduced using the original X-ray crystal structure of cephalostatin 1 and ROESY 2D nmr methods. Both cephalostatins 10 and 11 strongly inhibited growth of a series of important human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)52-63
Number of pages12
JournalJournal of Natural Products
Volume57
Issue number1
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Isolation and structure of cephalostatins 10 and 11'. Together they form a unique fingerprint.

Cite this