Isolation and structure of cephalostatins 10 and 11

George Pettit, Jun-Ping Xu, Michael D. Williams, Nigel D. Christie, Dennis L. Doubek, Jean M. Schmidt, Michael R. Boyd

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Further investigation of antineoplastic constituents from the marine worm Cephalodiscus gilchristi, employing a 450 kg re-collection from the Indian Ocean (Southeast Africa), has led to isolation and structural determination of two previously undetected members of the cephalostatin series, designated cephalostatins 10 [4] and 11 [5]. Structural analyses were conducted primarily employing high field 2D nmr and high resolution mass spectral techniques. All the stereochemical assignments were deduced using the original X-ray crystal structure of cephalostatin 1 and ROESY 2D nmr methods. Both cephalostatins 10 and 11 strongly inhibited growth of a series of important human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)52-63
Number of pages12
JournalJournal of Natural Products
Volume57
Issue number1
StatePublished - 1994

Fingerprint

Indian Ocean
crystal structure
Antineoplastic Agents
X-radiation
Crystal structure
Cells
cell lines
X-Rays
Cell Line
X rays
Growth
methodology
Neoplasms
cephalostatin 11
cephalostatin 10
cephalostatin I
neoplasm cells

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Pettit, G., Xu, J-P., Williams, M. D., Christie, N. D., Doubek, D. L., Schmidt, J. M., & Boyd, M. R. (1994). Isolation and structure of cephalostatins 10 and 11. Journal of Natural Products, 57(1), 52-63.

Isolation and structure of cephalostatins 10 and 11. / Pettit, George; Xu, Jun-Ping; Williams, Michael D.; Christie, Nigel D.; Doubek, Dennis L.; Schmidt, Jean M.; Boyd, Michael R.

In: Journal of Natural Products, Vol. 57, No. 1, 1994, p. 52-63.

Research output: Contribution to journalArticle

Pettit, G, Xu, J-P, Williams, MD, Christie, ND, Doubek, DL, Schmidt, JM & Boyd, MR 1994, 'Isolation and structure of cephalostatins 10 and 11', Journal of Natural Products, vol. 57, no. 1, pp. 52-63.
Pettit G, Xu J-P, Williams MD, Christie ND, Doubek DL, Schmidt JM et al. Isolation and structure of cephalostatins 10 and 11. Journal of Natural Products. 1994;57(1):52-63.
Pettit, George ; Xu, Jun-Ping ; Williams, Michael D. ; Christie, Nigel D. ; Doubek, Dennis L. ; Schmidt, Jean M. ; Boyd, Michael R. / Isolation and structure of cephalostatins 10 and 11. In: Journal of Natural Products. 1994 ; Vol. 57, No. 1. pp. 52-63.
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