Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae

George Pettit, Qinghua Ye, Delbert L. Herald, John C. Knight, Fiona Hogan, Noeleen Melody, Venugopal J R V Mukku, Dennis L. Doubek, Jean Chapuis

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The Zimbabwean medicinal plant Monadenium lugardae was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (1-4) were isolated, accompanied by four previously known triterpenes (5-8). Against a panel of human tumor cell lines, lugardstatins 1 (1) and 2 (2) had good cancer cell growth inhibitory activity. All of the triterpene structures (1-8) were established by 1D and 2D NMR spectrometric and HR mass spectrometric analysis.

Original languageEnglish (US)
Pages (from-to)1598-1603
Number of pages6
JournalJournal of Natural Products
Volume79
Issue number6
DOIs
StatePublished - Jun 24 2016

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

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    Pettit, G., Ye, Q., Herald, D. L., Knight, J. C., Hogan, F., Melody, N., Mukku, V. J. R. V., Doubek, D. L., & Chapuis, J. (2016). Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae. Journal of Natural Products, 79(6), 1598-1603. https://doi.org/10.1021/acs.jnatprod.6b00107