Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae

George Pettit, Qinghua Ye, Delbert L. Herald, John C. Knight, Fiona Hogan, Noeleen Melody, Venugopal J R V Mukku, Dennis L. Doubek, Jean Chapuis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Zimbabwean medicinal plant Monadenium lugardae was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (1-4) were isolated, accompanied by four previously known triterpenes (5-8). Against a panel of human tumor cell lines, lugardstatins 1 (1) and 2 (2) had good cancer cell growth inhibitory activity. All of the triterpene structures (1-8) were established by 1D and 2D NMR spectrometric and HR mass spectrometric analysis.

Original languageEnglish (US)
Pages (from-to)1598-1603
Number of pages6
JournalJournal of Natural Products
Volume79
Issue number6
DOIs
StatePublished - Jun 24 2016

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Triterpenes
Cell growth
Growth
Neoplasms
Medicinal Plants
Tumor Cell Line
Tumors
Cells
Nuclear magnetic resonance

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

Cite this

Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae. / Pettit, George; Ye, Qinghua; Herald, Delbert L.; Knight, John C.; Hogan, Fiona; Melody, Noeleen; Mukku, Venugopal J R V; Doubek, Dennis L.; Chapuis, Jean.

In: Journal of Natural Products, Vol. 79, No. 6, 24.06.2016, p. 1598-1603.

Research output: Contribution to journalArticle

Pettit, George ; Ye, Qinghua ; Herald, Delbert L. ; Knight, John C. ; Hogan, Fiona ; Melody, Noeleen ; Mukku, Venugopal J R V ; Doubek, Dennis L. ; Chapuis, Jean. / Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae. In: Journal of Natural Products. 2016 ; Vol. 79, No. 6. pp. 1598-1603.
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