Isolation and structure of bryostatins 14 and 15

George Pettit, F. Gao, D. Sengupta, J. C. Coll., C. L. Herald, D. L. Doubek, J. M. Schmidt, J. R. van Camp, J. J. Rudloe, R. A. Nieman

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Further investigation of constituents from the marine bryozoan Bugula neritina employing new 1,000 kg recollections from the Gulf of Mexico and Eastern Pacific Ocean (California) has led to isolation and structural determination of two previously undetected members of the bryostatin (1-13) series, bryostatins 14 (14) and 15 (15). Structural analyses were conducted primarily with high field (400 MHz) NMR and high resolution mass spectral techniques. Both new bryostatins significantly inhibited growth of the P388 lymphocytic leukemia.

Original languageEnglish (US)
Pages (from-to)3601-3610
Number of pages10
JournalTetrahedron
Volume47
Issue number22
DOIs
StatePublished - 1991

Fingerprint

Bryostatins
Gulf of Mexico
Pacific Ocean
Lymphoid Leukemia
Nuclear magnetic resonance
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Pettit, G., Gao, F., Sengupta, D., Coll., J. C., Herald, C. L., Doubek, D. L., ... Nieman, R. A. (1991). Isolation and structure of bryostatins 14 and 15. Tetrahedron, 47(22), 3601-3610. https://doi.org/10.1016/S0040-4020(01)80873-5

Isolation and structure of bryostatins 14 and 15. / Pettit, George; Gao, F.; Sengupta, D.; Coll., J. C.; Herald, C. L.; Doubek, D. L.; Schmidt, J. M.; van Camp, J. R.; Rudloe, J. J.; Nieman, R. A.

In: Tetrahedron, Vol. 47, No. 22, 1991, p. 3601-3610.

Research output: Contribution to journalArticle

Pettit, G, Gao, F, Sengupta, D, Coll., JC, Herald, CL, Doubek, DL, Schmidt, JM, van Camp, JR, Rudloe, JJ & Nieman, RA 1991, 'Isolation and structure of bryostatins 14 and 15', Tetrahedron, vol. 47, no. 22, pp. 3601-3610. https://doi.org/10.1016/S0040-4020(01)80873-5
Pettit G, Gao F, Sengupta D, Coll. JC, Herald CL, Doubek DL et al. Isolation and structure of bryostatins 14 and 15. Tetrahedron. 1991;47(22):3601-3610. https://doi.org/10.1016/S0040-4020(01)80873-5
Pettit, George ; Gao, F. ; Sengupta, D. ; Coll., J. C. ; Herald, C. L. ; Doubek, D. L. ; Schmidt, J. M. ; van Camp, J. R. ; Rudloe, J. J. ; Nieman, R. A. / Isolation and structure of bryostatins 14 and 15. In: Tetrahedron. 1991 ; Vol. 47, No. 22. pp. 3601-3610.
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