Abstract
The new cancer cell growth (human and murine) inhibitory (GI50 0.3 to 3.3 μg/ml) cyclo-octapeptide axinastatin 5 (2) was isolated in 3.8 x 10-7% yield from the Western Indian Ocean marine sponge Axinella cf. carteri. Structural elucidation was achieved by high field (400 and 500 MHz) 2 D-NMR techniques and the amino acid sequence was confirmed by results of NMR and high resolution mass spectral MS/MS interpretations. Other peptide cancer cell growth inhibitory constituents of this orange sponge were found to be the cyclic hepta- and octapeptides axinastatin 1 and hymenistatin 1 (1).
Original language | English (US) |
---|---|
Pages (from-to) | 2935-2940 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 4 |
Issue number | 24 |
DOIs | |
State | Published - Dec 22 1994 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry