Isolation and structure of axinastatin 5 from a republic of comoros marine sponge

George Pettit, Feng Gao, Jean M. Schmidt, Jean Chapuis, Ronald L. Cerny

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The new cancer cell growth (human and murine) inhibitory (GI50 0.3 to 3.3 μg/ml) cyclo-octapeptide axinastatin 5 (2) was isolated in 3.8 x 10-7% yield from the Western Indian Ocean marine sponge Axinella cf. carteri. Structural elucidation was achieved by high field (400 and 500 MHz) 2 D-NMR techniques and the amino acid sequence was confirmed by results of NMR and high resolution mass spectral MS/MS interpretations. Other peptide cancer cell growth inhibitory constituents of this orange sponge were found to be the cyclic hepta- and octapeptides axinastatin 1 and hymenistatin 1 (1).

Original languageEnglish (US)
Pages (from-to)2935-2940
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number24
DOIs
StatePublished - Dec 22 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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