Isolation and structure of 14,15β-Epoxyprieurianin from the South American tree Guarea guidona

Viera Lukac̀ova, Judith Polonsky, Christian Moretti, George Pettit, Jean M. Schmidt, Christian Moretti

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Cell growth inhibitory constituents of the French Guiana medicinal tree Guarea guidona L. Sleumer (also known as G. trichilioides, Meliaceae) were investigated by bioassay (PS in vitro) directed isolation procedures. A chloroform extract of the root bark was found to contain a new PS in vitro (ED50 0.47–0.74 µg/ml) active limonoid characterized (principally by 250 MHz nmr measurements) as 14,15β-epoxyprieurianin (10a). The root bark was also found to contain prieurianin (1, PS EDso 4.4–7.8 µg/ml) and 7-oxo-gedunin (9, PS inactive).

Original languageEnglish (US)
Pages (from-to)288-294
Number of pages7
JournalJournal of Natural Products
Volume45
Issue number3
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Lukac̀ova, V., Polonsky, J., Moretti, C., Pettit, G., Schmidt, J. M., & Moretti, C. (1982). Isolation and structure of 14,15β-Epoxyprieurianin from the South American tree Guarea guidona. Journal of Natural Products, 45(3), 288-294. https://doi.org/10.1021/np50021a010