Isolation and structure of 14,15β-Epoxyprieurianin from the South American tree Guarea guidona

Viera Lukac̀ova; Judith Polonsky; Christian Moretti; George Pettit; Jean M. Schmidt; Christian Moretti

doi:10.1021/np50021a010

Isolation and structure of 14,15β-Epoxyprieurianin from the South American tree Guarea guidona

Viera Lukac̀ova, Judith Polonsky, Christian Moretti, George Pettit, Jean M. Schmidt, Christian Moretti

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Cell growth inhibitory constituents of the French Guiana medicinal tree Guarea guidona L. Sleumer (also known as G. trichilioides, Meliaceae) were investigated by bioassay (PS in vitro) directed isolation procedures. A chloroform extract of the root bark was found to contain a new PS in vitro (ED₅₀ 0.47–0.74 µg/ml) active limonoid characterized (principally by 250 MHz nmr measurements) as 14,15β-epoxyprieurianin (10a). The root bark was also found to contain prieurianin (1, PS EDso 4.4–7.8 µg/ml) and 7-oxo-gedunin (9, PS inactive).

Original language	English (US)
Pages (from-to)	288-294
Number of pages	7
Journal	Journal of Natural Products
Volume	45
Issue number	3
DOIs	https://doi.org/10.1021/np50021a010
State	Published - 1982

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Isolation and structure of 14,15β-Epoxyprieurianin from the South American tree Guarea guidona",

abstract = "Cell growth inhibitory constituents of the French Guiana medicinal tree Guarea guidona L. Sleumer (also known as G. trichilioides, Meliaceae) were investigated by bioassay (PS in vitro) directed isolation procedures. A chloroform extract of the root bark was found to contain a new PS in vitro (ED50 0.47–0.74 µg/ml) active limonoid characterized (principally by 250 MHz nmr measurements) as 14,15β-epoxyprieurianin (10a). The root bark was also found to contain prieurianin (1, PS EDso 4.4–7.8 µg/ml) and 7-oxo-gedunin (9, PS inactive).",

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T1 - Isolation and structure of 14,15β-Epoxyprieurianin from the South American tree Guarea guidona

AU - Lukac̀ova, Viera

AU - Polonsky, Judith

AU - Moretti, Christian

AU - Pettit, George

AU - Schmidt, Jean M.

AU - Moretti, Christian

PY - 1982

Y1 - 1982

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AB - Cell growth inhibitory constituents of the French Guiana medicinal tree Guarea guidona L. Sleumer (also known as G. trichilioides, Meliaceae) were investigated by bioassay (PS in vitro) directed isolation procedures. A chloroform extract of the root bark was found to contain a new PS in vitro (ED50 0.47–0.74 µg/ml) active limonoid characterized (principally by 250 MHz nmr measurements) as 14,15β-epoxyprieurianin (10a). The root bark was also found to contain prieurianin (1, PS EDso 4.4–7.8 µg/ml) and 7-oxo-gedunin (9, PS inactive).

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Isolation and structure of 14,15β-Epoxyprieurianin from the South American tree Guarea guidona

Abstract

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