Isolation and Crystal Structure of Stylopeptide 1, A New Marine Porifera Cycloheptapeptide

George Pettit; Jayaram K. Srirangam; Delbert L. Herald; Jun-Ping Xu; Michael R. Boyd; Zbigniew Cichacz; Yoshiaki Kamano; Jean M. Schmidt; Karen L. Erickson

doi:10.1021/jo00130a027

Isolation and Crystal Structure of Stylopeptide 1, A New Marine Porifera Cycloheptapeptide

George Pettit, Jayaram K. Srirangam, Delbert L. Herald, Jun-Ping Xu, Michael R. Boyd, Zbigniew Cichacz, Yoshiaki Kamano, Jean M. Schmidt, Karen L. Erickson

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Stylopeptide 1 (1) was isolated respectively from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was accomplished by utilizing highfield (500 MHz) 2D-NMR experiments and confirmed by an X-ray crystal structure determination to provide the assignment cyclo(Pro-Leu-Ile-Phe-Ser-Pro-Ile). The absolute configuration of the new cycloheptapeptide was established by employing results of chiral gas chromatographic analyses.

Original language	English (US)
Pages (from-to)	8257-8261
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	60
Issue number	25
DOIs	https://doi.org/10.1021/jo00130a027
State	Published - Dec 1 1995

ASJC Scopus subject areas

Organic Chemistry

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title = "Isolation and Crystal Structure of Stylopeptide 1, A New Marine Porifera Cycloheptapeptide",

abstract = "Stylopeptide 1 (1) was isolated respectively from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was accomplished by utilizing highfield (500 MHz) 2D-NMR experiments and confirmed by an X-ray crystal structure determination to provide the assignment cyclo(Pro-Leu-Ile-Phe-Ser-Pro-Ile). The absolute configuration of the new cycloheptapeptide was established by employing results of chiral gas chromatographic analyses.",

author = "George Pettit and Srirangam, {Jayaram K.} and Herald, {Delbert L.} and Jun-Ping Xu and Boyd, {Michael R.} and Zbigniew Cichacz and Yoshiaki Kamano and Schmidt, {Jean M.} and Erickson, {Karen L.}",

year = "1995",

month = dec,

day = "1",

doi = "10.1021/jo00130a027",

language = "English (US)",

volume = "60",

pages = "8257--8261",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Isolation and Crystal Structure of Stylopeptide 1, A New Marine Porifera Cycloheptapeptide

AU - Pettit, George

AU - Srirangam, Jayaram K.

AU - Herald, Delbert L.

AU - Xu, Jun-Ping

AU - Boyd, Michael R.

AU - Cichacz, Zbigniew

AU - Kamano, Yoshiaki

AU - Schmidt, Jean M.

AU - Erickson, Karen L.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - Stylopeptide 1 (1) was isolated respectively from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was accomplished by utilizing highfield (500 MHz) 2D-NMR experiments and confirmed by an X-ray crystal structure determination to provide the assignment cyclo(Pro-Leu-Ile-Phe-Ser-Pro-Ile). The absolute configuration of the new cycloheptapeptide was established by employing results of chiral gas chromatographic analyses.

AB - Stylopeptide 1 (1) was isolated respectively from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was accomplished by utilizing highfield (500 MHz) 2D-NMR experiments and confirmed by an X-ray crystal structure determination to provide the assignment cyclo(Pro-Leu-Ile-Phe-Ser-Pro-Ile). The absolute configuration of the new cycloheptapeptide was established by employing results of chiral gas chromatographic analyses.

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DO - 10.1021/jo00130a027

M3 - Article

AN - SCOPUS:0029556701

SN - 0022-3263

VL - 60

SP - 8257

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 25

ER -

Isolation and Crystal Structure of Stylopeptide 1, A New Marine Porifera Cycloheptapeptide

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