Isolation and Crystal Structure of Stylopeptide 1, A New Marine Porifera Cycloheptapeptide

George Pettit, Jayaram K. Srirangam, Delbert L. Herald, Jun-Ping Xu, Michael R. Boyd, Zbigniew Cichacz, Yoshiaki Kamano, Jean M. Schmidt, Karen L. Erickson

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Abstract

Stylopeptide 1 (1) was isolated respectively from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was accomplished by utilizing highfield (500 MHz) 2D-NMR experiments and confirmed by an X-ray crystal structure determination to provide the assignment cyclo(Pro-Leu-Ile-Phe-Ser-Pro-Ile). The absolute configuration of the new cycloheptapeptide was established by employing results of chiral gas chromatographic analyses.

Original languageEnglish (US)
Pages (from-to)8257-8261
Number of pages5
JournalJournal of Organic Chemistry
Volume60
Issue number25
DOIs
StatePublished - Dec 1 1995

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ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Pettit, G., Srirangam, J. K., Herald, D. L., Xu, J-P., Boyd, M. R., Cichacz, Z., Kamano, Y., Schmidt, J. M., & Erickson, K. L. (1995). Isolation and Crystal Structure of Stylopeptide 1, A New Marine Porifera Cycloheptapeptide. Journal of Organic Chemistry, 60(25), 8257-8261. https://doi.org/10.1021/jo00130a027