Isolation and Crystal Structure of Stylopeptide 1, A New Marine Porifera Cycloheptapeptide

George Pettit, Jayaram K. Srirangam, Delbert L. Herald, Jun-Ping Xu, Michael R. Boyd, Zbigniew Cichacz, Yoshiaki Kamano, Jean M. Schmidt, Karen L. Erickson

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Stylopeptide 1 (1) was isolated respectively from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was accomplished by utilizing highfield (500 MHz) 2D-NMR experiments and confirmed by an X-ray crystal structure determination to provide the assignment cyclo(Pro-Leu-Ile-Phe-Ser-Pro-Ile). The absolute configuration of the new cycloheptapeptide was established by employing results of chiral gas chromatographic analyses.

Original languageEnglish (US)
Pages (from-to)8257-8261
Number of pages5
JournalJournal of Organic Chemistry
Volume60
Issue number25
DOIs
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Organic Chemistry

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