Isolation and Characterization of Strongylostatin 1

George Pettit; C. L. Herald; L. D. Vanell

doi:10.1021/np50004a008

Isolation and Characterization of Strongylostatin 1

George Pettit, C. L. Herald, L. D. Vanell

Research output: Contribution to journal › Article › peer-review

Abstract

The well-known green sea urchin Strongylocentrotus drobachiensis (Müller) has been found to contain a new glycoprotein antineoplastic agent. The glycoprotein was found to produce 35-53(7 life extension in the P388 murine lymphocytic leukemia system and has been designated strongylostatin 1. Because of the toxicity of strongylostatin 1 it may also be a constituent of Strongylocentrotus drobachiensis venom.

Original language	English (US)
Pages (from-to)	407-409
Number of pages	3
Journal	Journal of Natural Products
Volume	42
Issue number	4
DOIs	https://doi.org/10.1021/np50004a008
State	Published - Jan 1 1979

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Isolation and Characterization of Strongylostatin 1",

abstract = "The well-known green sea urchin Strongylocentrotus drobachiensis (M{\"u}ller) has been found to contain a new glycoprotein antineoplastic agent. The glycoprotein was found to produce 35-53(7 life extension in the P388 murine lymphocytic leukemia system and has been designated strongylostatin 1. Because of the toxicity of strongylostatin 1 it may also be a constituent of Strongylocentrotus drobachiensis venom.",

author = "George Pettit and Herald, {C. L.} and Vanell, {L. D.}",

year = "1979",

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AB - The well-known green sea urchin Strongylocentrotus drobachiensis (Müller) has been found to contain a new glycoprotein antineoplastic agent. The glycoprotein was found to produce 35-53(7 life extension in the P388 murine lymphocytic leukemia system and has been designated strongylostatin 1. Because of the toxicity of strongylostatin 1 it may also be a constituent of Strongylocentrotus drobachiensis venom.

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Isolation and Characterization of Strongylostatin 1

Abstract

ASJC Scopus subject areas

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