Isolation and characterization of strongylostatin

George Pettit, C. L. Herald, L. D. Vanell

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The well-known green sea urchin Strongylocentrotus drobachiensis (Müller) has been found to contain a new glycoprotein antineoplastic agent. The glycoprotein was found to produce 35-53% life extension in the P388 murine lymphocytic leukemia system and has been designated strongylostatin 1. Because of the toxicity of strongylostatin 1 it may also be a constituent of Strongylocentrotus drobachiensis venom.

Original languageEnglish (US)
Pages (from-to)407-409
Number of pages3
JournalJournal of Natural Products
Volume42
Issue number4
StatePublished - 1979

Fingerprint

Strongylocentrotus
glycoproteins
Glycoproteins
Strongylocentrotus nudus
Lymphoid Leukemia
lymphocytic leukemia
Sea Urchins
antineoplastic agents
Venoms
venoms
Life Expectancy
Antineoplastic Agents
Toxicity
toxicity
mice

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Pettit, G., Herald, C. L., & Vanell, L. D. (1979). Isolation and characterization of strongylostatin. Journal of Natural Products, 42(4), 407-409.

Isolation and characterization of strongylostatin. / Pettit, George; Herald, C. L.; Vanell, L. D.

In: Journal of Natural Products, Vol. 42, No. 4, 1979, p. 407-409.

Research output: Contribution to journalArticle

Pettit, G, Herald, CL & Vanell, LD 1979, 'Isolation and characterization of strongylostatin', Journal of Natural Products, vol. 42, no. 4, pp. 407-409.
Pettit, George ; Herald, C. L. ; Vanell, L. D. / Isolation and characterization of strongylostatin. In: Journal of Natural Products. 1979 ; Vol. 42, No. 4. pp. 407-409.
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