Isolation and characterization of palystatins A-D

George Pettit, Youichi Fujii, Julia A. Hasler, Jean M. Schmidt

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Four new and relatively low molecular weight (∼3,000–5,000), cell growth (PS) inhibitory peptides designated palystatins A–D have been isolated from the Indian Ocean Palythoa liscia Haddon and Duerden. The isolation utilized chromatographic procedures (Amberlite XAD-7 to Sephadex G-100) guided by bioassay with the P388 murine lymphocytic leukemia (PS system). Palystatins A–D exhibited PS cytotoxicity in the range ED50 0.02–0.0023 µg/ml.

Original languageEnglish (US)
Pages (from-to)272-276
Number of pages5
JournalJournal of Natural Products
Volume45
Issue number3
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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