Isolation and characterization of palystatins A-D

George Pettit; Youichi Fujii; Julia A. Hasler; Jean M. Schmidt

doi:10.1021/np50021a007

Isolation and characterization of palystatins A-D

George Pettit, Youichi Fujii, Julia A. Hasler, Jean M. Schmidt

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14 Scopus citations

Abstract

Four new and relatively low molecular weight (∼3,000–5,000), cell growth (PS) inhibitory peptides designated palystatins A–D have been isolated from the Indian Ocean Palythoa liscia Haddon and Duerden. The isolation utilized chromatographic procedures (Amberlite XAD-7 to Sephadex G-100) guided by bioassay with the P388 murine lymphocytic leukemia (PS system). Palystatins A–D exhibited PS cytotoxicity in the range ED₅₀ 0.02–0.0023 µg/ml.

Original language	English (US)
Pages (from-to)	272-276
Number of pages	5
Journal	Journal of Natural Products
Volume	45
Issue number	3
DOIs	https://doi.org/10.1021/np50021a007
State	Published - 1982

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50021a007

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abstract = "Four new and relatively low molecular weight (∼3,000–5,000), cell growth (PS) inhibitory peptides designated palystatins A–D have been isolated from the Indian Ocean Palythoa liscia Haddon and Duerden. The isolation utilized chromatographic procedures (Amberlite XAD-7 to Sephadex G-100) guided by bioassay with the P388 murine lymphocytic leukemia (PS system). Palystatins A–D exhibited PS cytotoxicity in the range ED50 0.02–0.0023 µg/ml.",

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T1 - Isolation and characterization of palystatins A-D

AU - Pettit, George

AU - Fujii, Youichi

AU - Hasler, Julia A.

AU - Schmidt, Jean M.

PY - 1982

Y1 - 1982

N2 - Four new and relatively low molecular weight (∼3,000–5,000), cell growth (PS) inhibitory peptides designated palystatins A–D have been isolated from the Indian Ocean Palythoa liscia Haddon and Duerden. The isolation utilized chromatographic procedures (Amberlite XAD-7 to Sephadex G-100) guided by bioassay with the P388 murine lymphocytic leukemia (PS system). Palystatins A–D exhibited PS cytotoxicity in the range ED50 0.02–0.0023 µg/ml.

AB - Four new and relatively low molecular weight (∼3,000–5,000), cell growth (PS) inhibitory peptides designated palystatins A–D have been isolated from the Indian Ocean Palythoa liscia Haddon and Duerden. The isolation utilized chromatographic procedures (Amberlite XAD-7 to Sephadex G-100) guided by bioassay with the P388 murine lymphocytic leukemia (PS system). Palystatins A–D exhibited PS cytotoxicity in the range ED50 0.02–0.0023 µg/ml.

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JO - Journal of Natural Products

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Isolation and characterization of palystatins A-D

Abstract

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