Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

Brad K. Carte, Charles DeBrosse, Drake Eggleston, Mark Hemling, Mary Mentzer, Benjamin Poehland, Nelson Troupe, John W. Westley, Sidney M. Hecht

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1).

Original languageEnglish (US)
Pages (from-to)2747-2760
Number of pages14
JournalTetrahedron
Volume46
Issue number8
DOIs
StatePublished - 1990
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Carte, B. K., DeBrosse, C., Eggleston, D., Hemling, M., Mentzer, M., Poehland, B., Troupe, N., Westley, J. W., & Hecht, S. M. (1990). Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata. Tetrahedron, 46(8), 2747-2760. https://doi.org/10.1016/S0040-4020(01)88369-1