Isofagomine, a Potent, New Glycosidase Inhibitor

Tina M. Jespersen; Wenling Dong; Michael R. Sierks; Troels Skrydstrup; Inge Lundt; Mikael Bols

doi:10.1002/anie.199417781

Isofagomine, a Potent, New Glycosidase Inhibitor

Tina M. Jespersen, Wenling Dong, Michael R. Sierks, Troels Skrydstrup, Inge Lundt, Mikael Bols

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

Abstract

Replacing the anomeric C atom of 2‐deoxy‐O‐glucose with an N atom and the ring O atom with a C atom leads to 1, the most potent β‐glycosidase inhibitor known to date. This synthetic monosaccharide derivative also inhibits other glucosidases better than naturally occurring sugar derivatives in which only the O atom in the ring is exchanged for an N atom. (Figure Presented.)

Original language	English (US)
Pages (from-to)	1778-1779
Number of pages	2
Journal	Angewandte Chemie International Edition in English
Volume	33
Issue number	17
DOIs	https://doi.org/10.1002/anie.199417781
State	Published - Sep 16 1994
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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abstract = "Replacing the anomeric C atom of 2‐deoxy‐O‐glucose with an N atom and the ring O atom with a C atom leads to 1, the most potent β‐glycosidase inhibitor known to date. This synthetic monosaccharide derivative also inhibits other glucosidases better than naturally occurring sugar derivatives in which only the O atom in the ring is exchanged for an N atom. (Figure Presented.)",

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T1 - Isofagomine, a Potent, New Glycosidase Inhibitor

AU - Jespersen, Tina M.

AU - Dong, Wenling

AU - Sierks, Michael R.

AU - Skrydstrup, Troels

AU - Lundt, Inge

AU - Bols, Mikael

PY - 1994/9/16

Y1 - 1994/9/16

N2 - Replacing the anomeric C atom of 2‐deoxy‐O‐glucose with an N atom and the ring O atom with a C atom leads to 1, the most potent β‐glycosidase inhibitor known to date. This synthetic monosaccharide derivative also inhibits other glucosidases better than naturally occurring sugar derivatives in which only the O atom in the ring is exchanged for an N atom. (Figure Presented.)

AB - Replacing the anomeric C atom of 2‐deoxy‐O‐glucose with an N atom and the ring O atom with a C atom leads to 1, the most potent β‐glycosidase inhibitor known to date. This synthetic monosaccharide derivative also inhibits other glucosidases better than naturally occurring sugar derivatives in which only the O atom in the ring is exchanged for an N atom. (Figure Presented.)

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Isofagomine, a Potent, New Glycosidase Inhibitor

Abstract

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