Isofagomine, a Potent, New Glycosidase Inhibitor

Tina M. Jespersen, Wenling Dong, Michael R. Sierks, Troels Skrydstrup, Inge Lundt, Mikael Bols

Research output: Contribution to journalArticlepeer-review

161 Scopus citations

Abstract

Replacing the anomeric C atom of 2‐deoxy‐O‐glucose with an N atom and the ring O atom with a C atom leads to 1, the most potent β‐glycosidase inhibitor known to date. This synthetic monosaccharide derivative also inhibits other glucosidases better than naturally occurring sugar derivatives in which only the O atom in the ring is exchanged for an N atom. (Figure Presented.)

Original languageEnglish (US)
Pages (from-to)1778-1779
Number of pages2
JournalAngewandte Chemie International Edition in English
Volume33
Issue number17
DOIs
StatePublished - Sep 16 1994
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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